Govindarajan B - Search Results

1

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

Govindarajan B, Sligh JE, Vincent BJ, Li M, Canter JA, Nickoloff BJ, Rodenburg RJ, Smeitink JA, Oberley L, Zhang Y, Slingerland J, Arnold RS, Lambeth JD, Cohen C, Hilenski L, Griendling K, Martínez-Diez M, Cuezva JM, Arbiser JL. Govindarajan B, et al. J Clin Invest. 2007 Mar;117(3):719-29. doi: 10.1172/JCI30102. Epub 2007 Feb 22. J Clin Invest. 2007. PMID: 17318262 Free PMC article.

2

Mitogen-actived protein kinase activation is an early event in melanoma progression.

Cohen C, Zavala-Pompa A, Sequeira JH, Shoji M, Sexton DG, Cotsonis G, Cerimele F, Govindarajan B, Macaron N, Arbiser JL. Cohen C, et al. Among authors: govindarajan b. Clin Cancer Res. 2002 Dec;8(12):3728-33. Clin Cancer Res. 2002. PMID: 12473582

3

Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.

Govindarajan B, Bai X, Cohen C, Zhong H, Kilroy S, Louis G, Moses M, Arbiser JL. Govindarajan B, et al. J Biol Chem. 2003 Mar 14;278(11):9790-5. doi: 10.1074/jbc.M212929200. Epub 2003 Jan 3. J Biol Chem. 2003. PMID: 12514183 Free article.

4

Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth.

Govindarajan B, Mizesko MC, Miller MS, Onda H, Nunnelley M, Casper K, Brat D, Cohen C, Arbiser JL. Govindarajan B, et al. Clin Cancer Res. 2003 Aug 15;9(9):3469-75. Clin Cancer Res. 2003. PMID: 12960139

5

Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.

Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL. Govindarajan B, et al. J Biol Chem. 2005 Apr 8;280(14):13936-43. doi: 10.1074/jbc.M500411200. Epub 2005 Feb 4. J Biol Chem. 2005. PMID: 15695519 Free article.

6

Wilms tumor 1 expression present in most melanomas but nearly absent in nevi.

Perry BN, Cohen C, Govindarajan B, Cotsonis G, Arbiser JL. Perry BN, et al. Among authors: govindarajan b. Arch Dermatol. 2006 Aug;142(8):1031-4. doi: 10.1001/archderm.142.8.1031. Arch Dermatol. 2006. PMID: 16924053

7

Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma.

Chua R, Setzer S, Govindarajan B, Sexton D, Cohen C, Arbiser JL. Chua R, et al. Among authors: govindarajan b. J Am Acad Dermatol. 2009 May;60(5):758-66. doi: 10.1016/j.jaad.2009.01.018. J Am Acad Dermatol. 2009. PMID: 19389518

8

Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.

Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL. Bhandarkar SS, et al. Among authors: govindarajan b. J Clin Invest. 2009 Aug;119(8):2359-65. doi: 10.1172/JCI33877. Epub 2009 Jul 13. J Clin Invest. 2009. PMID: 19620773 Free PMC article.

9

The antidepressant sertraline downregulates Akt and has activity against melanoma cells.

Reddy KK, Lefkove B, Chen LB, Govindarajan B, Carracedo A, Velasco G, Carrillo CO, Bhandarkar SS, Owens MJ, Mechta-Grigoriou F, Arbiser JL. Reddy KK, et al. Among authors: govindarajan b. Pigment Cell Melanoma Res. 2008 Aug;21(4):451-6. doi: 10.1111/j.1755-148X.2008.00481.x. Pigment Cell Melanoma Res. 2008. PMID: 18710373

10

Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo.

Bhandarkar SS, Bromberg J, Carrillo C, Selvakumar P, Sharma RK, Perry BN, Govindarajan B, Fried L, Sohn A, Reddy K, Arbiser JL. Bhandarkar SS, et al. Among authors: govindarajan b. Clin Cancer Res. 2008 Sep 15;14(18):5743-8. doi: 10.1158/1078-0432.CCR-08-0405. Clin Cancer Res. 2008. PMID: 18794083 Free PMC article.

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