Coffing SL - Search Results

1

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV Jr, Soliman VF, Schildknegt K. Kalgutkar AS, et al. Among authors: coffing sl. Drug Metab Dispos. 2007 Jun;35(6):848-58. doi: 10.1124/dmd.106.013649. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344339

2

Development and validation of an in vitro micronucleus assay platform in TK6 cells.

Sobol Z, Homiski ML, Dickinson DA, Spellman RA, Li D, Scott A, Cheung JR, Coffing SL, Munzner JB, Sanok KE, Gunther WC, Dobo KL, Schuler M. Sobol Z, et al. Among authors: coffing sl. Mutat Res. 2012 Jul 4;746(1):29-34. doi: 10.1016/j.mrgentox.2012.02.005. Epub 2012 Mar 13. Mutat Res. 2012. PMID: 22445949

3

Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds.

Schuler M, Tomlinson L, Homiski M, Cheung J, Zhan Y, Coffing S, Engel M, Rubitski E, Seitis G, Hales K, Robertson A, Vispute S, Cook J, Radi Z, Hollingshead B. Schuler M, et al. Toxicol Sci. 2021 Feb 26;180(1):103-121. doi: 10.1093/toxsci/kfaa189. Toxicol Sci. 2021. PMID: 33481035

4

Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in rats.

Dobo KL, Fiedler RD, Gunther WC, Thiffeault CJ, Cammerer Z, Coffing SL, Shutsky T, Schuler M. Dobo KL, et al. Among authors: coffing sl. Mutat Res. 2011 Oct 9;725(1-2):13-21. doi: 10.1016/j.mrgentox.2011.06.005. Epub 2011 Jun 24. Mutat Res. 2011. PMID: 21729764 Free PMC article.

5

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.

Cammerer Z, Bhalli JA, Cao X, Coffing SL, Dickinson D, Dobo KL, Dobrovolsky VN, Engel M, Fiedler RD, Gunther WC, Heflich RH, Pearce MG, Shaddock JG, Shutsky T, Thiffeault CJ, Schuler M. Cammerer Z, et al. Among authors: coffing sl. Environ Mol Mutagen. 2011 Dec;52(9):721-30. doi: 10.1002/em.20686. Environ Mol Mutagen. 2011. PMID: 22167886

6

Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.

Coffing SL, Kenyon MO, Ackerman JI, Shutsky TJ, Dobo KL. Coffing SL, et al. Environ Mol Mutagen. 2015 Apr;56(3):322-32. doi: 10.1002/em.21910. Epub 2014 Sep 17. Environ Mol Mutagen. 2015. PMID: 25229874

7

The rat gut micronucleus assay: a good choice for alternative in vivo genetic toxicology testing strategies.

Coffing S, Engel M, Dickinson D, Thiffeault C, Spellman R, Shutsky T, Schuler M. Coffing S, et al. Environ Mol Mutagen. 2011 May;52(4):269-79. doi: 10.1002/em.20616. Epub 2010 Sep 24. Environ Mol Mutagen. 2011. PMID: 20872852

8

Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.

Gunther WC, Coffing SL, Dickinson DA, Engel ME, Fiedler RD, O'Lone SD, Sanok KE, Thiffeault CJ, Shutsky TJ, Schuler MJ, Dobo KL. Gunther WC, et al. Among authors: coffing sl. Environ Mol Mutagen. 2014 Jul;55(6):492-9. doi: 10.1002/em.21863. Epub 2014 Mar 6. Environ Mol Mutagen. 2014. PMID: 24599777

9

Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.

Kenyon MO, Coffing SL, Ackerman JI, Gunther WC, Dertinger SD, Criswell K, Dobo KL. Kenyon MO, et al. Among authors: coffing sl. Mutagenesis. 2015 May;30(3):325-34. doi: 10.1093/mutage/geu051. Epub 2015 Mar 27. Mutagenesis. 2015. PMID: 25820171

10

2-Hydroxypyridine N-Oxide is not genotoxic in vivo.

Dobo KL, Coffing S, Gunther WC, Homiski M. Dobo KL, et al. Environ Mol Mutagen. 2019 Aug;60(7):588-593. doi: 10.1002/em.22294. Epub 2019 May 23. Environ Mol Mutagen. 2019. PMID: 31001845

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