Kalgutkar AS - Search Results

1

Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.

Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV Jr, Soliman VF, Schildknegt K. Kalgutkar AS, et al. Drug Metab Dispos. 2007 Jun;35(6):848-58. doi: 10.1124/dmd.106.013649. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344339

2

Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.

Kalgutkar AS, Dalvie DK, Castagnoli N Jr, Taylor TJ. Kalgutkar AS, et al. Chem Res Toxicol. 2001 Sep;14(9):1139-62. doi: 10.1021/tx010073b. Chem Res Toxicol. 2001. PMID: 11559028 Review. No abstract available.

3

Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.

Kuperman AV, Kalgutkar AS, Marfat A, Chambers RJ, Liston TE. Kuperman AV, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2001 Nov;29(11):1403-9. Drug Metab Dispos. 2001. PMID: 11602515

4

Biotransformation reactions of five-membered aromatic heterocyclic rings.

Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SC, Obach RS, O'Donnell JP. Dalvie DK, et al. Among authors: kalgutkar as. Chem Res Toxicol. 2002 Mar;15(3):269-99. doi: 10.1021/tx015574b. Chem Res Toxicol. 2002. PMID: 11896674 Review. No abstract available.

5

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.

Kalgutkar AS, Dalvie DK, O'Donnell JP, Taylor TJ, Sahakian DC. Kalgutkar AS, et al. Curr Drug Metab. 2002 Aug;3(4):379-424. doi: 10.2174/1389200023337360. Curr Drug Metab. 2002. PMID: 12093357 Review.

6

Pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat.

Trudeau-Lame ME, Kalgutkar AS, LaFontaine M. Trudeau-Lame ME, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2003 Feb;31(2):147-52. doi: 10.1124/dmd.31.2.147. Drug Metab Dispos. 2003. PMID: 12527695

7

Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.

Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM. Kalgutkar AS, et al. Drug Metab Dispos. 2003 Mar;31(3):243-9. doi: 10.1124/dmd.31.3.243. Drug Metab Dispos. 2003. PMID: 12584149

8

Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.

Kalgutkar AS, Zhou S, Fahmi OA, Taylor TJ. Kalgutkar AS, et al. Drug Metab Dispos. 2003 May;31(5):596-605. doi: 10.1124/dmd.31.5.596. Drug Metab Dispos. 2003. PMID: 12695348

9

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes.

Kalgutkar AS, Nguyen HT, Vaz AD, Doan A, Dalvie DK, McLeod DG, Murray JC. Kalgutkar AS, et al. Drug Metab Dispos. 2003 Oct;31(10):1240-50. doi: 10.1124/dmd.31.10.1240. Drug Metab Dispos. 2003. PMID: 12975333

10

Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.

O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS. O'Donnell JP, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2003 Nov;31(11):1369-77. doi: 10.1124/dmd.31.11.1369. Drug Metab Dispos. 2003. PMID: 14570769

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