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Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Fracchiolla G, Lavecchia A, Laghezza A, Piemontese L, Trisolini R, Carbonara G, Tortorella P, Novellino E, Loiodice F. Fracchiolla G, et al. Among authors: carbonara g. Bioorg Med Chem. 2008 Nov 1;16(21):9498-510. doi: 10.1016/j.bmc.2008.09.045. Epub 2008 Sep 19. Bioorg Med Chem. 2008. PMID: 18835719
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Di Giovanni C, Carbonara G, Tortorella P, Novellino E, Loiodice F. Fracchiolla G, et al. Among authors: carbonara g. Bioorg Med Chem. 2012 Mar 15;20(6):2141-51. doi: 10.1016/j.bmc.2012.01.025. Epub 2012 Jan 28. Bioorg Med Chem. 2012. PMID: 22341573
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.
Carrieri A, Giudici M, Parente M, De Rosas M, Piemontese L, Fracchiolla G, Laghezza A, Tortorella P, Carbonara G, Lavecchia A, Gilardi F, Crestani M, Loiodice F. Carrieri A, et al. Among authors: carbonara g. Eur J Med Chem. 2013 May;63:321-32. doi: 10.1016/j.ejmech.2013.02.015. Epub 2013 Feb 24. Eur J Med Chem. 2013. PMID: 23502212
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.
Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F. Piemontese L, et al. Among authors: carbonara g. Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24. Eur J Med Chem. 2015. PMID: 25497132
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study.
Lavecchia A, Cosconati S, Novellino E, Calleri E, Temporini C, Massolini G, Carbonara G, Fracchiolla G, Loiodice F. Lavecchia A, et al. Among authors: carbonara g. J Mol Graph Model. 2007 Mar;25(6):773-83. doi: 10.1016/j.jmgm.2006.07.001. Epub 2006 Aug 8. J Mol Graph Model. 2007. PMID: 16901739
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity.
Temporini C, Calleri E, Fracchiolla G, Carbonara G, Loiodice F, Lavecchia A, Tortorella P, Brusotti G, Massolini G. Temporini C, et al. Among authors: carbonara g. J Pharm Biomed Anal. 2007 Oct 18;45(2):211-8. doi: 10.1016/j.jpba.2007.06.005. Epub 2007 Jun 12. J Pharm Biomed Anal. 2007. PMID: 17629437
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels.
Tricarico D, Mele A, Camerino GM, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Camerino DC. Tricarico D, et al. Among authors: carbonara g. Mol Pharmacol. 2008 Jul;74(1):50-8. doi: 10.1124/mol.108.046615. Epub 2008 Apr 10. Mol Pharmacol. 2008. PMID: 18403717
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists.
Ammazzalorso A, Carrieri A, Verginelli F, Bruno I, Carbonara G, D'Angelo A, De Filippis B, Fantacuzzi M, Florio R, Fracchiolla G, Giampietro L, Giancristofaro A, Maccallini C, Cama A, Amoroso R. Ammazzalorso A, et al. Among authors: carbonara g. Eur J Med Chem. 2016 May 23;114:191-200. doi: 10.1016/j.ejmech.2016.02.064. Epub 2016 Feb 27. Eur J Med Chem. 2016. PMID: 26974385
36 results