Broyde S - Search Results

1

A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV.

Wang L, Yu X, Hu P, Broyde S, Zhang Y. Wang L, et al. Among authors: broyde s. J Am Chem Soc. 2007 Apr 18;129(15):4731-7. doi: 10.1021/ja068821c. Epub 2007 Mar 22. J Am Chem Soc. 2007. PMID: 17375926 Free PMC article.

2

Stereochemical, structural, and thermodynamic origins of stability differences between stereoisomeric benzo[a]pyrene diol epoxide deoxyadenosine adducts in a DNA mutational hot spot sequence.

Yan S, Shapiro R, Geacintov NE, Broyde S. Yan S, et al. Among authors: broyde s. J Am Chem Soc. 2001 Jul 25;123(29):7054-66. doi: 10.1021/ja0043035. J Am Chem Soc. 2001. PMID: 11459484

3

Accurate representation of B-DNA double helical structure with implicit solvent and counterions.

Wang L, Hingerty BE, Srinivasan AR, Olson WK, Broyde S. Wang L, et al. Among authors: broyde s. Biophys J. 2002 Jul;83(1):382-406. doi: 10.1016/S0006-3495(02)75177-1. Biophys J. 2002. PMID: 12080128 Free PMC article.

4

Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus.

Yang L, Beard W, Wilson S, Roux B, Broyde S, Schlick T. Yang L, et al. Among authors: broyde s. J Mol Biol. 2002 Aug 16;321(3):459-78. doi: 10.1016/s0022-2836(02)00617-4. J Mol Biol. 2002. PMID: 12162959

5

Substrate discrimination by formamidopyrimidine-DNA glycosylase: a mutational analysis.

Zaika EI, Perlow RA, Matz E, Broyde S, Gilboa R, Grollman AP, Zharkov DO. Zaika EI, et al. Among authors: broyde s. J Biol Chem. 2004 Feb 6;279(6):4849-61. doi: 10.1074/jbc.M310262200. Epub 2003 Nov 7. J Biol Chem. 2004. PMID: 14607836 Free article.

6

Structural and stereoisomer effects of model estrogen quinone-derived DNA adducts: N6-(2-hydroxyestron-6(alpha,beta)-yl)-2'-deoxyadenosine and N2-(2-hydroxyestron-6(alpha,beta)-yl)-2'-deoxyguanosine.

Wang L, Hingerty BE, Shapiro R, Broyde S. Wang L, et al. Among authors: broyde s. Chem Res Toxicol. 2004 Mar;17(3):311-24. doi: 10.1021/tx034218l. Chem Res Toxicol. 2004. PMID: 15025501

7

Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template.

Yan SF, Wu M, Geacintov NE, Broyde S. Yan SF, et al. Among authors: broyde s. Biochemistry. 2004 Jun 22;43(24):7750-65. doi: 10.1021/bi0499516. Biochemistry. 2004. PMID: 15196018

8

The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.

Perlow-Poehnelt RA, Likhterov I, Scicchitano DA, Geacintov NE, Broyde S. Perlow-Poehnelt RA, et al. Among authors: broyde s. J Biol Chem. 2004 Aug 27;279(35):36951-61. doi: 10.1074/jbc.M404332200. Epub 2004 Jun 21. J Biol Chem. 2004. PMID: 15210693 Free article.

9

Substrate discrimination by formamidopyrimidine-DNA glycosylase: distinguishing interactions within the active site.

Perlow-Poehnelt RA, Zharkov DO, Grollman AP, Broyde S. Perlow-Poehnelt RA, et al. Among authors: broyde s. Biochemistry. 2004 Dec 28;43(51):16092-105. doi: 10.1021/bi048747f. Biochemistry. 2004. PMID: 15610004

10

Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.

Wang L, Wu M, Yan SF, Patel DJ, Geacintov NE, Broyde S. Wang L, et al. Among authors: broyde s. Chem Res Toxicol. 2005 Mar;18(3):441-56. doi: 10.1021/tx049786v. Chem Res Toxicol. 2005. PMID: 15777084 Free PMC article.

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