Adlington RM - Search Results

1

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

Howard-Jones AR, Elkins JM, Clifton IJ, Roach PL, Adlington RM, Baldwin JE, Rutledge PJ. Howard-Jones AR, et al. Among authors: adlington rm. Biochemistry. 2007 Apr 24;46(16):4755-62. doi: 10.1021/bi062314q. Epub 2007 Mar 31. Biochemistry. 2007. PMID: 17397141

2

Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.

Elkins JM, Rutledge PJ, Burzlaff NI, Clifton IJ, Adlington RM, Roach PL, Baldwin JE. Elkins JM, et al. Among authors: adlington rm. Org Biomol Chem. 2003 May 7;1(9):1455-60. doi: 10.1039/b212270g. Org Biomol Chem. 2003. PMID: 12926272

3

Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase.

Howard-Jones AR, Rutledge PJ, Clifton IJ, Adlington RM, Baldwin JE. Howard-Jones AR, et al. Among authors: adlington rm. Biochem Biophys Res Commun. 2005 Oct 21;336(2):702-8. doi: 10.1016/j.bbrc.2005.08.155. Biochem Biophys Res Commun. 2005. PMID: 16143309

4

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase.

Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. Daruzzaman A, et al. Among authors: adlington rm. Chembiochem. 2006 Feb;7(2):351-8. doi: 10.1002/cbic.200500282. Chembiochem. 2006. PMID: 16444759

5

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase.

Stewart AC, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. Stewart AC, et al. Among authors: adlington rm. Chembiochem. 2007 Nov 5;8(16):2003-7. doi: 10.1002/cbic.200700176. Chembiochem. 2007. PMID: 17907118

6

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Ge W, et al. Among authors: adlington rm. J Am Chem Soc. 2008 Aug 6;130(31):10096-102. doi: 10.1021/ja8005397. Epub 2008 Jul 12. J Am Chem Soc. 2008. PMID: 18620394

7

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.

Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Ge W, et al. Among authors: adlington rm. Chembiochem. 2009 Aug 17;10(12):2025-31. doi: 10.1002/cbic.200900080. Chembiochem. 2009. PMID: 19598184

8

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Ge W, et al. Among authors: adlington rm. Org Biomol Chem. 2010 Jan 7;8(1):122-7. doi: 10.1039/b910170e. Epub 2009 Oct 29. Org Biomol Chem. 2010. PMID: 20024142

9

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ. Ge W, et al. Among authors: adlington rm. Biochem Biophys Res Commun. 2010 Aug 6;398(4):659-64. doi: 10.1016/j.bbrc.2010.06.129. Epub 2010 Jul 13. Biochem Biophys Res Commun. 2010. PMID: 20603104

10

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.

Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ. Clifton IJ, et al. Among authors: adlington rm. Chembiochem. 2011 Aug 16;12(12):1881-5. doi: 10.1002/cbic.201100149. Epub 2011 Jun 15. Chembiochem. 2011. PMID: 21678539

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