Nickols GA - Search Results

1

R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.

Nagarajan SR, Devadas B, Malecha JW, Lu HF, Ruminski PG, Rico JG, Rogers TE, Marrufo LD, Collins JT, Kleine HP, Lantz MK, Zhu J, Green NF, Russell MA, Landis BH, Miller LM, Meyer DM, Duffin TD, Engleman VW, Finn MB, Freeman SK, Griggs DW, Williams ML, Nickols MA, Pegg JA, Shannon KE, Steininger C, Westlin MM, Nickols GA, Keene JL. Nagarajan SR, et al. Among authors: nickols ga. Bioorg Med Chem. 2007 Jun 1;15(11):3783-800. doi: 10.1016/j.bmc.2007.03.034. Epub 2007 Mar 15. Bioorg Med Chem. 2007. PMID: 17399986

2

Discovery of diphenylmethanepropionic and dihydrostilbeneacetic acids as antagonists of the integrin alphavbeta3.

Nagarajan SR, Meyer JM, Miyashiro JM, Engleman VW, Freeman SK, Griggs DW, Klover JA, Nickols GA. Nagarajan SR, et al. Among authors: nickols ga. Chem Biol Drug Des. 2006 Feb;67(2):177-81. doi: 10.1111/j.1747-0285.2006.00344.x. Chem Biol Drug Des. 2006. PMID: 16492166

3

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.

Nagarajan SR, Lu HF, Gasiecki AF, Khanna IK, Parikh MD, Desai BN, Rogers TE, Clare M, Chen BB, Russell MA, Keene JL, Duffin T, Engleman VW, Finn MB, Freeman SK, Klover JA, Nickols GA, Nickols MA, Shannon KE, Steininger CA, Westlin WF, Westlin MM, Williams ML. Nagarajan SR, et al. Among authors: nickols ga. Bioorg Med Chem. 2007 May 15;15(10):3390-412. doi: 10.1016/j.bmc.2007.03.020. Epub 2007 Mar 13. Bioorg Med Chem. 2007. PMID: 17387018

4

A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.

Carron CP, Meyer DM, Pegg JA, Engleman VW, Nickols MA, Settle SL, Westlin WF, Ruminski PG, Nickols GA. Carron CP, et al. Among authors: nickols ga, nickols ma. Cancer Res. 1998 May 1;58(9):1930-5. Cancer Res. 1998. PMID: 9581835

5

Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone.

Carron CP, Meyer DM, Engleman VW, Rico JG, Ruminski PG, Ornberg RL, Westlin WF, Nickols GA. Carron CP, et al. Among authors: nickols ga. J Endocrinol. 2000 Jun;165(3):587-98. doi: 10.1677/joe.0.1650587. J Endocrinol. 2000. PMID: 10828842

6

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

Engleman VW, Nickols GA, Ross FP, Horton MA, Griggs DW, Settle SL, Ruminski PG, Teitelbaum SL. Engleman VW, et al. Among authors: nickols ga. J Clin Invest. 1997 May 1;99(9):2284-92. doi: 10.1172/JCI119404. J Clin Invest. 1997. PMID: 9151803 Free PMC article.

7

Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry.

Schmidt CM, Settle SL, Keene JL, Westlin WF, Nickols GA, Griggs DW. Schmidt CM, et al. Among authors: nickols ga. Clin Exp Metastasis. 1999;17(6):537-44. doi: 10.1023/a:1006719800907. Clin Exp Metastasis. 1999. PMID: 10763921

8

Antibody to beta3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat.

Crippes BA, Engleman VW, Settle SL, Delarco J, Ornberg RL, Helfrich MH, Horton MA, Nickols GA. Crippes BA, et al. Among authors: nickols ga. Endocrinology. 1996 Mar;137(3):918-24. doi: 10.1210/endo.137.3.8603604. Endocrinology. 1996. PMID: 8603604

9

Binding of parathyroid hormone and parathyroid hormone-related protein to vascular smooth muscle of rabbit renal microvessels.

Nickols GA, Nickols MA, Helwig JJ. Nickols GA, et al. Among authors: nickols ma. Endocrinology. 1990 Feb;126(2):721-7. doi: 10.1210/endo-126-2-721. Endocrinology. 1990. PMID: 2298168

10

Reassessment of noradrenergic function in salt-induced hypertension in Dahl rats.

Yamamoto R, Nickols GA, Nickols MA, DiPette DJ, Townsend RR, Takasaki K. Yamamoto R, et al. Among authors: nickols ga, nickols ma. Jpn J Pharmacol. 1992;58 Suppl 2:274P. Jpn J Pharmacol. 1992. PMID: 1507547 Free article. No abstract available.

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