DiGrandi M - Search Results

1

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J. Nittoli T, et al. Among authors: digrandi m. J Med Chem. 2007 May 3;50(9):2108-16. doi: 10.1021/jm061428x. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402724

2

Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV.

Bloom JD, DiGrandi MJ, Dushin RG, Curran KJ, Ross AA, Norton EB, Terefenko E, Jones TR, Feld B, Lang SA. Bloom JD, et al. Among authors: digrandi mj. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2929-32. doi: 10.1016/s0960-894x(03)00586-9. Bioorg Med Chem Lett. 2003. PMID: 14611860

3

Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.

Bloom JD, Dushin RG, Curran KJ, Donahue F, Norton EB, Terefenko E, Jones TR, Ross AA, Feld B, Lang SA, DiGrandi MJ. Bloom JD, et al. Among authors: digrandi mj. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3401-6. doi: 10.1016/j.bmcl.2004.04.093. Bioorg Med Chem Lett. 2004. PMID: 15177441

4

Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus.

Di Grandi MJ, Curran KJ, Feigelson G, Prashad A, Ross AA, Visalli R, Fairhurst J, Feld B, Bloom JD. Di Grandi MJ, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4157-60. doi: 10.1016/j.bmcl.2004.06.025. Bioorg Med Chem Lett. 2004. PMID: 15261261

5

Small molecule inhibitors of HIV RT Ribonuclease H.

Di Grandi M, Olson M, Prashad AS, Bebernitz G, Luckay A, Mullen S, Hu Y, Krishnamurthy G, Pitts K, O'Connell J. Di Grandi M, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):398-402. doi: 10.1016/j.bmcl.2009.10.043. Epub 2009 Oct 15. Bioorg Med Chem Lett. 2010. PMID: 19939680

6

Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties.

Di Grandi MJ, Curran KJ, Baum EZ, Bebernitz G, Ellestad GA, Ding WD, Lang SA, Rossi M, Bloom JD. Di Grandi MJ, et al. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3483-6. doi: 10.1016/s0960-894x(03)00789-3. Bioorg Med Chem Lett. 2003. PMID: 14505653

7

Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.

Di Grandi MJ, Berger DM, Hopper DW, Zhang C, Dutia M, Dunnick AL, Torres N, Levin JI, Diamantidis G, Zapf CW, Bloom JD, Hu Y, Powell D, Wojciechowicz D, Collins K, Frommer E. Di Grandi MJ, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6957-61. doi: 10.1016/j.bmcl.2009.10.058. Epub 2009 Oct 28. Bioorg Med Chem Lett. 2009. PMID: 19875283

8

Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication.

Visalli RJ, Fairhurst J, Srinivas S, Hu W, Feld B, DiGrandi M, Curran K, Ross A, Bloom JD, van Zeijl M, Jones TR, O'Connell J, Cohen JI. Visalli RJ, et al. Among authors: digrandi m. J Virol. 2003 Feb;77(4):2349-58. doi: 10.1128/jvi.77.4.2349-2358.2003. J Virol. 2003. PMID: 12551972 Free PMC article.

9

Inhibition of influenza A virus replication by compounds interfering with the fusogenic function of the viral hemagglutinin.

Plotch SJ, O'Hara B, Morin J, Palant O, LaRocque J, Bloom JD, Lang SA Jr, DiGrandi MJ, Bradley M, Nilakantan R, Gluzman Y. Plotch SJ, et al. Among authors: digrandi mj. J Virol. 1999 Jan;73(1):140-51. doi: 10.1128/JVI.73.1.140-151.1999. J Virol. 1999. PMID: 9847316 Free PMC article.

10

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

Hu Y, Xiang JS, DiGrandi MJ, Du X, Ipek M, Laakso LM, Li J, Li W, Rush TS, Schmid J, Skotnicki JS, Tam S, Thomason JR, Wang Q, Levin JI. Hu Y, et al. Among authors: digrandi mj. Bioorg Med Chem. 2005 Dec 15;13(24):6629-44. doi: 10.1016/j.bmc.2005.07.076. Epub 2005 Oct 10. Bioorg Med Chem. 2005. PMID: 16216515

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