Lalani AS - Search Results

1

Selective tumor targeting by the hypoxia-activated prodrug AQ4N blocks tumor growth and metastasis in preclinical models of pancreatic cancer.

Lalani AS, Alters SE, Wong A, Albertella MR, Cleland JL, Henner WD. Lalani AS, et al. Clin Cancer Res. 2007 Apr 1;13(7):2216-25. doi: 10.1158/1078-0432.CCR-06-2427. Clin Cancer Res. 2007. PMID: 17404106

2

Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study.

Albertella MR, Loadman PM, Jones PH, Phillips RM, Rampling R, Burnet N, Alcock C, Anthoney A, Vjaters E, Dunk CR, Harris PA, Wong A, Lalani AS, Twelves CJ. Albertella MR, et al. Among authors: lalani as. Clin Cancer Res. 2008 Feb 15;14(4):1096-104. doi: 10.1158/1078-0432.CCR-07-4020. Clin Cancer Res. 2008. PMID: 18281542 Free article. Clinical Trial.

3

A phase 1 open-label, accelerated dose-escalation study of the hypoxia-activated prodrug AQ4N in patients with advanced malignancies.

Papadopoulos KP, Goel S, Beeram M, Wong A, Desai K, Haigentz M, Milián ML, Mani S, Tolcher A, Lalani AS, Sarantopoulos J. Papadopoulos KP, et al. Among authors: lalani as. Clin Cancer Res. 2008 Nov 1;14(21):7110-5. doi: 10.1158/1078-0432.CCR-08-0483. Clin Cancer Res. 2008. PMID: 18981010 Clinical Trial.

4

Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy.

Li B, Lalani AS, Harding TC, Luan B, Koprivnikar K, Huan Tu G, Prell R, VanRoey MJ, Simmons AD, Jooss K. Li B, et al. Among authors: lalani as. Clin Cancer Res. 2006 Nov 15;12(22):6808-16. doi: 10.1158/1078-0432.CCR-06-1558. Clin Cancer Res. 2006. PMID: 17121902

5

The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone.

Trédan O, Garbens AB, Lalani AS, Tannock IF. Trédan O, et al. Among authors: lalani as. Cancer Res. 2009 Feb 1;69(3):940-7. doi: 10.1158/0008-5472.CAN-08-0676. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176397

6

C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial.

Beer TM, Lalani AS, Lee S, Mori M, Eilers KM, Curd JG, Henner WD, Ryan CW, Venner P, Ruether JD, Chi KN; ASCENT Investigators. Beer TM, et al. Among authors: lalani as. Cancer. 2008 Jun;112(11):2377-83. doi: 10.1002/cncr.23461. Cancer. 2008. PMID: 18428198 Free article. Clinical Trial.

7

Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor.

Lin J, Lalani AS, Harding TC, Gonzalez M, Wu WW, Luan B, Tu GH, Koprivnikar K, VanRoey MJ, He Y, Alitalo K, Jooss K. Lin J, et al. Among authors: lalani as. Cancer Res. 2005 Aug 1;65(15):6901-9. doi: 10.1158/0008-5472.CAN-05-0408. Cancer Res. 2005. PMID: 16061674

8

Combining Neratinib with CDK4/6, mTOR, and MEK Inhibitors in Models of HER2-positive Cancer.

Zhao M, Scott S, Evans KW, Yuca E, Saridogan T, Zheng X, Wang H, Korkut A, Cruz Pico CX, Demirhan M, Kirby B, Kopetz S, Diala I, Lalani AS, Piha-Paul S, Meric-Bernstam F. Zhao M, et al. Among authors: lalani as. Clin Cancer Res. 2021 Mar 15;27(6):1681-1694. doi: 10.1158/1078-0432.CCR-20-3017. Epub 2021 Jan 7. Clin Cancer Res. 2021. PMID: 33414137 Free PMC article.

9

Biomarker Analysis of the Phase III NALA Study of Neratinib + Capecitabine versus Lapatinib + Capecitabine in Patients with Previously Treated Metastatic Breast Cancer.

Saura C, Matito J, Oliveira M, Wildiers H, Brufksy AM, Waters SH, Hurvitz SA, Moy B, Kim SB, Gradishar WJ, Queiroz GS, Cronemberger E, Wallweber GJ, Bebchuk J, Keyvanjah K, Lalani AS, Bryce R, Vivancos A, Eli LD, Delaloge S. Saura C, et al. Among authors: lalani as. Clin Cancer Res. 2021 Nov 1;27(21):5818-5827. doi: 10.1158/1078-0432.CCR-21-1584. Epub 2021 Aug 11. Clin Cancer Res. 2021. PMID: 34380637 Free PMC article. Clinical Trial.

10

Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.

Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD, Thurston G. Daly C, et al. Among authors: lalani as. Cancer Res. 2013 Jan 1;73(1):108-18. doi: 10.1158/0008-5472.CAN-12-2064. Epub 2012 Nov 13. Cancer Res. 2013. PMID: 23149917

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