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SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.
Bertram LS, Black D, Briner PH, Chatfield R, Cooke A, Fyfe MC, Murray PJ, Naud F, Nawano M, Procter MJ, Rakipovski G, Rasamison CM, Reynet C, Schofield KL, Shah VK, Spindler F, Taylor A, Turton R, Williams GM, Wong-Kai-In P, Yasuda K. Bertram LS, et al. Among authors: fyfe mc. J Med Chem. 2008 Jul 24;51(14):4340-5. doi: 10.1021/jm8003202. Epub 2008 Jun 28. J Med Chem. 2008. PMID: 18588279
Glucokinase-activating ureas.
Castelhano AL, Dong H, Fyfe MC, Gardner LS, Kamikozawa Y, Kurabayashi S, Nawano M, Ohashi R, Procter MJ, Qiu L, Rasamison CM, Schofield KL, Shah VK, Ueta K, Williams GM, Witter D, Yasuda K. Castelhano AL, et al. Among authors: fyfe mc. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1501-4. doi: 10.1016/j.bmcl.2004.12.083. Bioorg Med Chem Lett. 2005. PMID: 15713416
Non-systemic Intestine-Targeted Drugs.
Fyfe MC. Fyfe MC. Prog Med Chem. 2016;55:1-44. doi: 10.1016/bs.pmch.2015.10.001. Epub 2016 Jan 12. Prog Med Chem. 2016. PMID: 26852933 Review. No abstract available.
27 results