Widdowson PS - Search Results

1

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.

Fyfe MC, White JR, Taylor A, Chatfield R, Wargent E, Printz RL, Sulpice T, McCormack JG, Procter MJ, Reynet C, Widdowson PS, Wong-Kai-In P. Fyfe MC, et al. Among authors: widdowson ps. Diabetologia. 2007 Jun;50(6):1277-87. doi: 10.1007/s00125-007-0646-8. Epub 2007 Apr 6. Diabetologia. 2007. PMID: 17415548

2

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.

Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C. Overton HA, et al. Among authors: widdowson ps. Cell Metab. 2006 Mar;3(3):167-75. doi: 10.1016/j.cmet.2006.02.004. Cell Metab. 2006. PMID: 16517404 Free article.

3

5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats.

Thomas GH, Babbs AJ, Chatfield RE, Krülle TM, Widdowson PS, Provost D, McCormack JG. Thomas GH, et al. Among authors: widdowson ps. Obesity (Silver Spring). 2009 Mar;17(3):467-73. doi: 10.1038/oby.2008.550. Epub 2008 Dec 11. Obesity (Silver Spring). 2009. PMID: 19219064 Free article.

4

Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.

Upton R, Widdowson PS, Ishii S, Tanaka H, Williams G. Upton R, et al. Among authors: widdowson ps. Br J Pharmacol. 1998 Dec;125(8):1708-14. doi: 10.1038/sj.bjp.0702245. Br J Pharmacol. 1998. PMID: 9886762 Free PMC article.

5

Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat.

Pickavance LC, Widdowson PS, Foster JR, Williams G, Wilding JP. Pickavance LC, et al. Among authors: widdowson ps. Int J Exp Pathol. 2003 Apr;84(2):83-9. doi: 10.1046/j.1365-2613.2003.00337.x. Int J Exp Pathol. 2003. PMID: 12801282 Free PMC article.

6

The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment.

Pickavance L, Widdowson PS, King P, Ishii S, Tanaka H, Williams G. Pickavance L, et al. Among authors: widdowson ps. Br J Pharmacol. 1998 Oct;125(4):767-70. doi: 10.1038/sj.bjp.0702158. Br J Pharmacol. 1998. PMID: 9831913 Free PMC article.

7

Neurobiology.

Wilding J, Widdowson P, Williams G. Wilding J, et al. Br Med Bull. 1997;53(2):286-306. doi: 10.1093/oxfordjournals.bmb.a011614. Br Med Bull. 1997. PMID: 9246837 Review.

8

Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat.

Widdowson PS, Upton R, Henderson L, Buckingham R, Wilson S, Williams G. Widdowson PS, et al. Brain Res. 1997 Nov 7;774(1-2):1-10. doi: 10.1016/s0006-8993(97)81680-0. Brain Res. 1997. PMID: 9452185

9

Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats.

Harrold JA, Williams G, Widdowson PS. Harrold JA, et al. Among authors: widdowson ps. Biochem Biophys Res Commun. 1999 May 19;258(3):574-7. doi: 10.1006/bbrc.1999.0675. Biochem Biophys Res Commun. 1999. PMID: 10329427

10

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.

Harrold JA, Widdowson PS, Williams G. Harrold JA, et al. Among authors: widdowson ps. Diabetes. 1999 Feb;48(2):267-71. doi: 10.2337/diabetes.48.2.267. Diabetes. 1999. PMID: 10334300

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