Zhang N - Search Results

1

2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization.

Zhang N, Ayral-Kaloustian S, Nguyen T, Hernandez R, Beyer C. Zhang N, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3003-5. doi: 10.1016/j.bmcl.2007.03.070. Epub 2007 Mar 25. Bioorg Med Chem Lett. 2007. PMID: 17416524

2

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

Wissner A, Berger DM, Boschelli DH, Floyd MB Jr, Greenberger LM, Gruber BC, Johnson BD, Mamuya N, Nilakantan R, Reich MF, Shen R, Tsou HR, Upeslacis E, Wang YF, Wu B, Ye F, Zhang N. Wissner A, et al. Among authors: zhang n. J Med Chem. 2000 Aug 24;43(17):3244-56. doi: 10.1021/jm000206a. J Med Chem. 2000. PMID: 10966743

3

Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.

Zhang N, Wu B, Powell D, Wissner A, Floyd MB, Kovacs ED, Toral-Barza L, Kohler C. Zhang N, et al. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2825-8. doi: 10.1016/s0960-894x(00)00580-1. Bioorg Med Chem Lett. 2000. PMID: 11133101

4

Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles.

Boschelli DH, Wang YD, Ye F, Wu B, Zhang N, Dutia M, Powell DW, Wissner A, Arndt K, Weber JM, Boschelli F. Boschelli DH, et al. Among authors: zhang n. J Med Chem. 2001 Mar 1;44(5):822-33. doi: 10.1021/jm000420z. J Med Chem. 2001. PMID: 11262092

5

MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines.

Zhang N, Wu B, Eudy N, Wang Y, Ye F, Powell D, Wissner A, Feldberg LR, Kim SC, Mallon R, Kovacs ED, Toral-Barza L, Kohler CA. Zhang N, et al. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1407-10. doi: 10.1016/s0960-894x(01)00238-4. Bioorg Med Chem Lett. 2001. PMID: 11378365

6

4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.

Zhang N, Wu B, Wissner A, Powell DW, Rabindran SK, Kohler C, Boschelli F. Zhang N, et al. Bioorg Med Chem Lett. 2002 Feb 11;12(3):423-5. doi: 10.1016/s0960-894x(01)00776-4. Bioorg Med Chem Lett. 2002. PMID: 11814812

7

Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.

Boschelli DH, Wang DY, Ye F, Yamashita A, Zhang N, Powell D, Weber J, Boschelli F. Boschelli DH, et al. Among authors: zhang n. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2011-4. doi: 10.1016/s0960-894x(02)00302-5. Bioorg Med Chem Lett. 2002. PMID: 12113830

8

Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.

Berger D, Dutia M, Powell D, Wu B, Wissner A, Boschelli DH, Floyd MB, Zhang N, Torres N, Levin J, Du X, Wojciechowicz D, Discafani C, Kohler C, Kim SC, Feldberg LR, Collins K, Mallon R. Berger D, et al. Among authors: zhang n. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3031-4. doi: 10.1016/s0960-894x(03)00640-1. Bioorg Med Chem Lett. 2003. PMID: 12941327

9

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.

Gopalsamy A, Yang H, Ellingboe JW, Tsou HR, Zhang N, Honores E, Powell D, Miranda M, McGinnis JP, Rabindran SK. Gopalsamy A, et al. Among authors: zhang n. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1591-4. doi: 10.1016/j.bmcl.2005.01.066. Bioorg Med Chem Lett. 2005. PMID: 15745803

10

Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition.

Zhang N, Ayral-Kaloustian S, Nguyen T, Afragola J, Hernandez R, Lucas J, Gibbons J, Beyer C. Zhang N, et al. J Med Chem. 2007 Jan 25;50(2):319-27. doi: 10.1021/jm060717i. J Med Chem. 2007. PMID: 17228873

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