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Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype.
Kalb R, Neveling K, Hoehn H, Schneider H, Linka Y, Batish SD, Hunt C, Berwick M, Callen E, Surralles J, Casado JA, Bueren J, Dasi A, Soulier J, Gluckman E, Zwaan CM, van Spaendonk R, Pals G, de Winter JP, Joenje H, Grompe M, Auerbach AD, Hanenberg H, Schindler D. Kalb R, et al. Among authors: callen e. Am J Hum Genet. 2007 May;80(5):895-910. doi: 10.1086/517616. Epub 2007 Apr 6. Am J Hum Genet. 2007. PMID: 17436244 Free PMC article.
Active DNA demethylation promotes cell fate specification and the DNA damage response.
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Wang D, et al. Among authors: callen e. Science. 2022 Dec 2;378(6623):983-989. doi: 10.1126/science.add9838. Epub 2022 Dec 1. Science. 2022. PMID: 36454826 Free PMC article.
Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization.
Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Zagelbaum J, et al. Among authors: callen e. Nat Struct Mol Biol. 2023 Jul;30(7):1048. doi: 10.1038/s41594-023-00994-w. Nat Struct Mol Biol. 2023. PMID: 37059902 Free PMC article. No abstract available.
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells.
Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Urya H, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MA. Zhang L, et al. Among authors: callen e. bioRxiv [Preprint]. 2024 Jan 17:2023.08.31.555634. doi: 10.1101/2023.08.31.555634. bioRxiv. 2024. Update in: Elife. 2024 Jun 18;12:RP91611. doi: 10.7554/eLife.91611 PMID: 37693622 Free PMC article. Updated. Preprint.
EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells.
van de Kooij B, Schreuder A, Pavani RS, Garzero V, Van Hoeck A, San Martin Alonso M, Koerse D, Wendel TJ, Callen E, Boom J, Mei H, Cuppen E, Nussenzweig A, van Attikum H, Noordermeer SM. van de Kooij B, et al. Among authors: callen e. bioRxiv [Preprint]. 2023 Feb 24:2023.02.24.529205. doi: 10.1101/2023.02.24.529205. bioRxiv. 2023. PMID: 37720033 Free PMC article. Preprint.
115 results