Sircar I - Search Results

1

Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists.

Xie YF, Lake K, Ligsay K, Komandla M, Sircar I, Nagarajan G, Li J, Xu K, Parise J, Schneider L, Huang D, Liu J, Dines K, Sakurai N, Barbosa M, Jack R. Xie YF, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3367-72. doi: 10.1016/j.bmcl.2007.03.104. Epub 2007 Apr 5. Bioorg Med Chem Lett. 2007. PMID: 17446072

2

Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.

Bakir F, Kher S, Pannala M, Wilson N, Nguyen T, Sircar I, Takedomi K, Fukushima C, Zapf J, Xu K, Zhang SH, Liu J, Morera L, Schneider L, Sakurai N, Jack R, Cheng JF. Bakir F, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3473-9. doi: 10.1016/j.bmcl.2007.03.076. Epub 2007 Mar 27. Bioorg Med Chem Lett. 2007. PMID: 17416521

3

2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.

Kher S, Lake K, Sircar I, Pannala M, Bakir F, Zapf J, Xu K, Zhang SH, Liu J, Morera L, Sakurai N, Jack R, Cheng JF. Kher S, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4442-6. doi: 10.1016/j.bmcl.2007.06.017. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17587573

4

Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.

Pannala M, Kher S, Wilson N, Gaudette J, Sircar I, Zhang SH, Bakhirev A, Yang G, Yuen P, Gorcsan F, Sakurai N, Barbosa M, Cheng JF. Pannala M, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5978-82. doi: 10.1016/j.bmcl.2007.07.071. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17827009

5

Identification of novel series of human CCR1 antagonists.

Xie YF, Sircar I, Lake K, Komandla M, Ligsay K, Li J, Xu K, Parise J, Schneider L, Huang D, Liu J, Sakurai N, Barbosa M, Jack R. Xie YF, et al. Among authors: sircar i. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2215-21. doi: 10.1016/j.bmcl.2007.09.068. Epub 2007 Sep 25. Bioorg Med Chem Lett. 2008. PMID: 18329267

6

Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist.

Sircar I, Gudmundsson KS, Martin R, Liang J, Nomura S, Jayakumar H, Teegarden BR, Nowlin DM, Cardarelli PM, Mah JR, Connell S, Griffith RC, Lazarides E. Sircar I, et al. Bioorg Med Chem. 2002 Jun;10(6):2051-66. doi: 10.1016/s0968-0896(02)00021-4. Bioorg Med Chem. 2002. PMID: 11937364

7

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.

Doherty AM, Sircar I, Kornberg BE, Quin J 3rd, Winters RT, Kaltenbronn JS, Taylor MD, Batley BL, Rapundalo SR, Ryan MJ, et al. Doherty AM, et al. Among authors: sircar i. J Med Chem. 1992 Jan;35(1):2-14. doi: 10.1021/jm00079a001. J Med Chem. 1992. PMID: 1732531

8

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.

Sircar I, Winters RT, Quin J 3rd, Lu GH, Major TC, Panek RL. Sircar I, et al. J Med Chem. 1993 Jun 11;36(12):1735-45. doi: 10.1021/jm00064a007. J Med Chem. 1993. PMID: 8510101

9

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

Edmunds JJ, Klutchko S, Hamby JM, Bunker AM, Connolly CJ, Winters RT, Quin J 3rd, Sircar I, Hodges JC, Panek RL, et al. Edmunds JJ, et al. Among authors: sircar i. J Med Chem. 1995 Sep 15;38(19):3759-71. doi: 10.1021/jm00019a005. J Med Chem. 1995. PMID: 7562906

10

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).

Sircar I, Hodges JC, Quin J 3rd, Bunker AM, Winters RT, Edmunds JJ, Kostlan CR, Connolly C, Kesten SJ, Hamby JM, et al. Sircar I, et al. J Med Chem. 1993 Aug 6;36(16):2253-65. doi: 10.1021/jm00068a002. J Med Chem. 1993. PMID: 8360871

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