Chiou W - Search Results

1

Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.

Zhao G, Iyengar RR, Judd AS, Cool B, Chiou W, Kifle L, Frevert E, Sham H, Kym PR. Zhao G, et al. Among authors: chiou w. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3254-7. doi: 10.1016/j.bmcl.2007.04.011. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17451949

2

Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase.

Anderson SN, Cool BL, Kifle L, Chiou W, Egan DA, Barrett LW, Richardson PL, Frevert EU, Warrior U, Kofron JL, Burns DJ. Anderson SN, et al. Among authors: chiou w. J Biomol Screen. 2004 Mar;9(2):112-21. doi: 10.1177/1087057103260592. J Biomol Screen. 2004. PMID: 15006134

3

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, Dickinson R, Adler A, Gagne G, Iyengar R, Zhao G, Marsh K, Kym P, Jung P, Camp HS, Frevert E. Cool B, et al. Among authors: chiou w. Cell Metab. 2006 Jun;3(6):403-16. doi: 10.1016/j.cmet.2006.05.005. Cell Metab. 2006. PMID: 16753576 Free article.

4

Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.

Rohde JJ, Pliushchev MA, Sorensen BK, Wodka D, Shuai Q, Wang J, Fung S, Monzon KM, Chiou WJ, Pan L, Deng X, Chovan LE, Ramaiya A, Mullally M, Henry RF, Stolarik DF, Imade HM, Marsh KC, Beno DW, Fey TA, Droz BA, Brune ME, Camp HS, Sham HL, Frevert EU, Jacobson PB, Link JT. Rohde JJ, et al. Among authors: chiou wj. J Med Chem. 2007 Jan 11;50(1):149-64. doi: 10.1021/jm0609364. J Med Chem. 2007. PMID: 17201418

5

Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.

Sorensen B, Rohde J, Wang J, Fung S, Monzon K, Chiou W, Pan L, Deng X, Stolarik D, Frevert EU, Jacobson P, Link JT. Sorensen B, et al. Among authors: chiou w. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5958-62. doi: 10.1016/j.bmcl.2006.08.129. Epub 2006 Sep 25. Bioorg Med Chem Lett. 2006. PMID: 16996734

6

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT. Sorensen B, et al. Among authors: chiou w. Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. doi: 10.1016/j.bmcl.2006.10.008. Epub 2006 Oct 7. Bioorg Med Chem Lett. 2007. PMID: 17070044

7

Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.

Patel JR, Shuai Q, Dinges J, Winn M, Pliushchev M, Fung S, Monzon K, Chiou W, Wang J, Pan L, Wagaw S, Engstrom K, Kerdesky FA, Longenecker K, Judge R, Qin W, Imade HM, Stolarik D, Beno DW, Brune M, Chovan LE, Sham HL, Jacobson P, Link JT. Patel JR, et al. Among authors: chiou w. Bioorg Med Chem Lett. 2007 Feb 1;17(3):750-5. doi: 10.1016/j.bmcl.2006.10.074. Epub 2006 Oct 28. Bioorg Med Chem Lett. 2007. PMID: 17110106

8

Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.

Yeh VS, Kurukulasuriya R, Madar D, Patel JR, Fung S, Monzon K, Chiou W, Wang J, Jacobson P, Sham HL, Link JT. Yeh VS, et al. Among authors: chiou w. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5408-13. doi: 10.1016/j.bmcl.2006.07.062. Epub 2006 Aug 4. Bioorg Med Chem Lett. 2006. PMID: 16890427

9

Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.

Yeh VS, Patel JR, Yong H, Kurukulasuriya R, Fung S, Monzon K, Chiou W, Wang J, Stolarik D, Imade H, Beno D, Brune M, Jacobson P, Sham H, Link JT. Yeh VS, et al. Among authors: chiou w. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5414-9. doi: 10.1016/j.bmcl.2006.07.055. Epub 2006 Aug 8. Bioorg Med Chem Lett. 2006. PMID: 16899366

10

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET(A) receptor selectivity.

Boyd SA, Mantei RA, Tasker AS, Liu G, Sorensen BK, Henry KJ Jr, von Geldern TW, Winn M, Wu-Wong JR, Chiou WJ, Dixon DB, Hutchins CW, Marsh KC, Nguyen B, Opgenorth TJ. Boyd SA, et al. Among authors: chiou wj. Bioorg Med Chem. 1999 Jun;7(6):991-1002. doi: 10.1016/s0968-0896(99)00022-x. Bioorg Med Chem. 1999. PMID: 10428367

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