Cool B - Search Results

1

Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.

Zhao G, Iyengar RR, Judd AS, Cool B, Chiou W, Kifle L, Frevert E, Sham H, Kym PR. Zhao G, et al. Among authors: cool b. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3254-7. doi: 10.1016/j.bmcl.2007.04.011. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17451949

2

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, Dickinson R, Adler A, Gagne G, Iyengar R, Zhao G, Marsh K, Kym P, Jung P, Camp HS, Frevert E. Cool B, et al. Cell Metab. 2006 Jun;3(6):403-16. doi: 10.1016/j.cmet.2006.05.005. Cell Metab. 2006. PMID: 16753576 Free article.

3

Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase.

Anderson SN, Cool BL, Kifle L, Chiou W, Egan DA, Barrett LW, Richardson PL, Frevert EU, Warrior U, Kofron JL, Burns DJ. Anderson SN, et al. Among authors: cool bl. J Biomol Screen. 2004 Mar;9(2):112-21. doi: 10.1177/1087057103260592. J Biomol Screen. 2004. PMID: 15006134

4

Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.

Stewart AO, Bhatia PA, McCarty CM, Patel MV, Staeger MA, Arendsen DL, Gunawardana IW, Melcher LM, Zhu GD, Boyd SA, Fry DG, Cool BL, Kifle L, Lartey K, Marsh KC, Kempf-Grote AJ, Kilgannon P, Wisdom W, Meyer J, Gallatin WM, Okasinski GF. Stewart AO, et al. Among authors: cool bl. J Med Chem. 2001 Mar 15;44(6):988-1002. doi: 10.1021/jm000452m. J Med Chem. 2001. PMID: 11300880

5

Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.

Zhu GD, Arendsen DL, Gunawardana IW, Boyd SA, Stewart AO, Fry DG, Cool BL, Kifle L, Schaefer V, Meuth J, Marsh KC, Kempf-Grote AJ, Kilgannon P, Gallatin WM, Okasinski GF. Zhu GD, et al. Among authors: cool bl. J Med Chem. 2001 Oct 11;44(21):3469-87. doi: 10.1021/jm0101702. J Med Chem. 2001. PMID: 11585452

6

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.

Mishra R, Cool BL, Laderoute KR, Foretz M, Viollet B, Simonson MS. Mishra R, et al. Among authors: cool bl. J Biol Chem. 2008 Apr 18;283(16):10461-9. doi: 10.1074/jbc.M800902200. Epub 2008 Feb 4. J Biol Chem. 2008. PMID: 18250161 Free article.

7

A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons.

Cool BH, Chan GC, Lee L, Oshima J, Martin GM, Hu Q. Cool BH, et al. PLoS One. 2010 Apr 26;5(4):e10351. doi: 10.1371/journal.pone.0010351. PLoS One. 2010. PMID: 20436672 Free PMC article.

8

Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.

Cool BH, Zitnik G, Martin GM, Hu Q. Cool BH, et al. J Neurochem. 2010 Jan;112(2):410-9. doi: 10.1111/j.1471-4159.2009.06456.x. Epub 2009 Oct 27. J Neurochem. 2010. PMID: 19860855 Free PMC article.

9

A dominant role for FE65 (APBB1) in nuclear signaling.

Yang Z, Cool BH, Martin GM, Hu Q. Yang Z, et al. Among authors: cool bh. J Biol Chem. 2006 Feb 17;281(7):4207-14. doi: 10.1074/jbc.M508445200. Epub 2005 Dec 6. J Biol Chem. 2006. PMID: 16332686 Free article.

10

Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates.

Hu Q, Wang L, Yang Z, Cool BH, Zitnik G, Martin GM. Hu Q, et al. Among authors: cool bh. J Biol Chem. 2005 Apr 1;280(13):12548-58. doi: 10.1074/jbc.M411855200. Epub 2005 Jan 12. J Biol Chem. 2005. PMID: 15647266 Free article.

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