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Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice.
Leinhase I, Rozanski M, Harhausen D, Thurman JM, Schmidt OI, Hossini AM, Taha ME, Rittirsch D, Ward PA, Holers VM, Ertel W, Stahel PF. Leinhase I, et al. J Neuroinflammation. 2007 May 2;4:13. doi: 10.1186/1742-2094-4-13. J Neuroinflammation. 2007. PMID: 17474994 Free PMC article. Clinical Trial.
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.
Leinhase I, Schmidt OI, Thurman JM, Hossini AM, Rozanski M, Taha ME, Scheffler A, John T, Smith WR, Holers VM, Stahel PF. Leinhase I, et al. Exp Neurol. 2006 Jun;199(2):454-64. doi: 10.1016/j.expneurol.2006.01.033. Epub 2006 Mar 20. Exp Neurol. 2006. PMID: 16545803
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