Crooke RM - Search Results

1

Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.

Imai Y, Varela GM, Jackson MB, Graham MJ, Crooke RM, Ahima RS. Imai Y, et al. Among authors: crooke rm. Gastroenterology. 2007 May;132(5):1947-54. doi: 10.1053/j.gastro.2007.02.046. Epub 2007 Feb 23. Gastroenterology. 2007. PMID: 17484887

2

Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets.

Faleck DM, Ali K, Roat R, Graham MJ, Crooke RM, Battisti R, Garcia E, Ahima RS, Imai Y. Faleck DM, et al. Among authors: crooke rm. Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E249-57. doi: 10.1152/ajpendo.00646.2009. Epub 2010 May 18. Am J Physiol Endocrinol Metab. 2010. PMID: 20484013 Free PMC article.

3

Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.

Carr RM, Patel RT, Rao V, Dhir R, Graham MJ, Crooke RM, Ahima RS. Carr RM, et al. Among authors: crooke rm. Am J Physiol Regul Integr Comp Physiol. 2012 Apr 15;302(8):R996-1003. doi: 10.1152/ajpregu.00177.2011. Epub 2012 Feb 29. Am J Physiol Regul Integr Comp Physiol. 2012. PMID: 22378776 Free PMC article.

4

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.

Liu Y, Millar JS, Cromley DA, Graham M, Crooke R, Billheimer JT, Rader DJ. Liu Y, et al. Biochim Biophys Acta. 2008 Mar;1781(3):97-104. doi: 10.1016/j.bbalip.2008.01.001. Epub 2008 Jan 17. Biochim Biophys Acta. 2008. PMID: 18252207

5

In vivo antisense oligonucleotide reduction of NPC1 expression as a novel mouse model for Niemann Pick type C- associated liver disease.

Rimkunas VM, Graham MJ, Crooke RM, Liscum L. Rimkunas VM, et al. Among authors: crooke rm. Hepatology. 2008 May;47(5):1504-12. doi: 10.1002/hep.22327. Hepatology. 2008. PMID: 18438776 Free PMC article.

6

Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism.

Li G, Hernandez-Ono A, Crooke RM, Graham MJ, Ginsberg HN. Li G, et al. Among authors: crooke rm. J Lipid Res. 2011 May;52(5):971-81. doi: 10.1194/jlr.M013748. Epub 2011 Mar 1. J Lipid Res. 2011. PMID: 21364201 Free PMC article.

7

Modulation of lipoprotein metabolism by antisense technology: preclinical drug discovery methodology.

Crooke RM, Graham MJ. Crooke RM, et al. Methods Mol Biol. 2013;1027:309-24. doi: 10.1007/978-1-60327-369-5_14. Methods Mol Biol. 2013. PMID: 23912993

8

Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes.

Digenio A, Dunbar RL, Alexander VJ, Hompesch M, Morrow L, Lee RG, Graham MJ, Hughes SG, Yu R, Singleton W, Baker BF, Bhanot S, Crooke RM. Digenio A, et al. Among authors: crooke rm. Diabetes Care. 2016 Aug;39(8):1408-15. doi: 10.2337/dc16-0126. Epub 2016 Jun 6. Diabetes Care. 2016. PMID: 27271183 Clinical Trial.

9

Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB. Sun X, et al. Among authors: crooke rm. J Biol Chem. 2016 Jan 15;291(3):1115-22. doi: 10.1074/jbc.M115.668269. Epub 2015 Oct 28. J Biol Chem. 2016. PMID: 26511317 Free PMC article.

10

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis.

Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ. Crooke RM, et al. J Lipid Res. 2005 May;46(5):872-84. doi: 10.1194/jlr.M400492-JLR200. Epub 2005 Feb 16. J Lipid Res. 2005. PMID: 15716585 Free article.

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