Strynadka NC - Search Results

1

The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.

Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stütz AE, Vasella A, Withers SG, Strynadka NC. Caines ME, et al. Among authors: strynadka nc. Angew Chem Int Ed Engl. 2007;46(24):4474-6. doi: 10.1002/anie.200700268. Angew Chem Int Ed Engl. 2007. PMID: 17487923 No abstract available.

2

Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.

Persson K, Ly HD, Dieckelmann M, Wakarchuk WW, Withers SG, Strynadka NC. Persson K, et al. Among authors: strynadka nc. Nat Struct Biol. 2001 Feb;8(2):166-75. doi: 10.1038/84168. Nat Struct Biol. 2001. PMID: 11175908

3

One step closer to a sweet conclusion.

Withers SG, Wakarchuk WW, Strynadka NC. Withers SG, et al. Among authors: strynadka nc. Chem Biol. 2002 Dec;9(12):1270-3. doi: 10.1016/s1074-5521(02)00291-0. Chem Biol. 2002. PMID: 12498879 Review.

4

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.

Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC. Chiu CP, et al. Among authors: strynadka nc. Nat Struct Mol Biol. 2004 Feb;11(2):163-70. doi: 10.1038/nsmb720. Epub 2004 Jan 18. Nat Struct Mol Biol. 2004. PMID: 14730352

5

Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.

Lairson LL, Chiu CP, Ly HD, He S, Wakarchuk WW, Strynadka NC, Withers SG. Lairson LL, et al. Among authors: strynadka nc. J Biol Chem. 2004 Jul 2;279(27):28339-44. doi: 10.1074/jbc.M400451200. Epub 2004 Apr 9. J Biol Chem. 2004. PMID: 15075344 Free article.

6

Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate.

Lovering AL, Lee SS, Kim YW, Withers SG, Strynadka NC. Lovering AL, et al. Among authors: strynadka nc. J Biol Chem. 2005 Jan 21;280(3):2105-15. doi: 10.1074/jbc.M410468200. Epub 2004 Oct 22. J Biol Chem. 2005. PMID: 15501829 Free article.

7

Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex.

Kim YW, Lovering AL, Chen H, Kantner T, McIntosh LP, Strynadka NC, Withers SG. Kim YW, et al. Among authors: strynadka nc. J Am Chem Soc. 2006 Feb 22;128(7):2202-3. doi: 10.1021/ja057904a. J Am Chem Soc. 2006. PMID: 16478160

8

High-throughput screening methodology for the directed evolution of glycosyltransferases.

Aharoni A, Thieme K, Chiu CP, Buchini S, Lairson LL, Chen H, Strynadka NC, Wakarchuk WW, Withers SG. Aharoni A, et al. Among authors: strynadka nc. Nat Methods. 2006 Aug;3(8):609-14. doi: 10.1038/nmeth899. Nat Methods. 2006. PMID: 16862135

9

Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms.

Caines ME, Vaughan MD, Tarling CA, Hancock SM, Warren RA, Withers SG, Strynadka NC. Caines ME, et al. Among authors: strynadka nc. J Biol Chem. 2007 May 11;282(19):14300-8. doi: 10.1074/jbc.M611455200. Epub 2007 Feb 28. J Biol Chem. 2007. PMID: 17329247 Free article.

10

Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms.

Chiu CP, Lairson LL, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Chiu CP, et al. Among authors: strynadka nc. Biochemistry. 2007 Jun 19;46(24):7196-204. doi: 10.1021/bi602543d. Epub 2007 May 23. Biochemistry. 2007. PMID: 17518445

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