Tarling CA - Search Results

1

The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.

Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stütz AE, Vasella A, Withers SG, Strynadka NC. Caines ME, et al. Among authors: tarling ca. Angew Chem Int Ed Engl. 2007;46(24):4474-6. doi: 10.1002/anie.200700268. Angew Chem Int Ed Engl. 2007. PMID: 17487923 No abstract available.

2

The synthesis of a series of modified mannotrisaccharides as probes of the enzymes involved in the early stages of mammalian complex N-glycan formation.

Tarling CA, Withers SG. Tarling CA, et al. Carbohydr Res. 2004 Oct 20;339(15):2487-97. doi: 10.1016/j.carres.2004.08.007. Carbohydr Res. 2004. PMID: 15476709

3

Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms.

Caines ME, Vaughan MD, Tarling CA, Hancock SM, Warren RA, Withers SG, Strynadka NC. Caines ME, et al. Among authors: tarling ca. J Biol Chem. 2007 May 11;282(19):14300-8. doi: 10.1074/jbc.M611455200. Epub 2007 Feb 28. J Biol Chem. 2007. PMID: 17329247 Free article.

4

Probing electrostatic interactions along the reaction pathway of a glycoside hydrolase: histidine characterization by NMR spectroscopy.

Schubert M, Poon DK, Wicki J, Tarling CA, Kwan EM, Nielsen JE, Withers SG, McIntosh LP. Schubert M, et al. Among authors: tarling ca. Biochemistry. 2007 Jun 26;46(25):7383-95. doi: 10.1021/bi700249m. Epub 2007 Jun 5. Biochemistry. 2007. PMID: 17547373

5

Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols--a proof-of-concept study.

Steiner AJ, Stütz AE, Wrodnigg TM, Tarling CA, Withers SG, Hermetter A, Schmidinger H. Steiner AJ, et al. Among authors: tarling ca. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1922-5. doi: 10.1016/j.bmcl.2008.01.124. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18281216

6

High-throughput screening of cell lysates for ganglioside synthesis.

Hancock SM, Tarling CA, Withers SG. Hancock SM, et al. Among authors: tarling ca. Anal Biochem. 2008 Nov 1;382(1):48-54. doi: 10.1016/j.ab.2008.07.023. Epub 2008 Jul 29. Anal Biochem. 2008. PMID: 18703011

7

Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen.

Kuntz DA, Tarling CA, Withers SG, Rose DR. Kuntz DA, et al. Among authors: tarling ca. Biochemistry. 2008 Sep 23;47(38):10058-68. doi: 10.1021/bi8010785. Epub 2008 Aug 30. Biochemistry. 2008. PMID: 18759458

8

Chitinase inhibition by chitobiose and chitotriose thiazolines.

Macdonald JM, Tarling CA, Taylor EJ, Dennis RJ, Myers DS, Knapp S, Davies GJ, Withers SG. Macdonald JM, et al. Among authors: tarling ca. Angew Chem Int Ed Engl. 2010 Mar 29;49(14):2599-602. doi: 10.1002/anie.200906644. Angew Chem Int Ed Engl. 2010. PMID: 20209544 No abstract available.

9

Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding.

Varrot A, Tarling CA, Macdonald JM, Stick RV, Zechel DL, Withers SG, Davies GJ. Varrot A, et al. Among authors: tarling ca. J Am Chem Soc. 2003 Jun 25;125(25):7496-7. doi: 10.1021/ja034917k. J Am Chem Soc. 2003. PMID: 12812472

10

Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics.

Lundt I, Steiner AJ, Stütz AE, Tarling CA, Ully S, Withers SG, Wrodnigg TM. Lundt I, et al. Among authors: tarling ca. Bioorg Med Chem. 2006 Mar 15;14(6):1737-42. doi: 10.1016/j.bmc.2005.10.021. Epub 2005 Nov 7. Bioorg Med Chem. 2006. PMID: 16274997

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