Withers SG - Search Results

1

The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.

Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stütz AE, Vasella A, Withers SG, Strynadka NC. Caines ME, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2007;46(24):4474-6. doi: 10.1002/anie.200700268. Angew Chem Int Ed Engl. 2007. PMID: 17487923 No abstract available.

2

Ternary complex crystal structures of glycogen phosphorylase with the transition state analogue nojirimycin tetrazole and phosphate in the T and R states.

Mitchell EP, Withers SG, Ermert P, Vasella AT, Garman EF, Oikonomakos NG, Johnson LN. Mitchell EP, et al. Among authors: withers sg. Biochemistry. 1996 Jun 11;35(23):7341-55. doi: 10.1021/bi960072w. Biochemistry. 1996. PMID: 8652510

3

Glycosidase mechanisms.

Rye CS, Withers SG. Rye CS, et al. Among authors: withers sg. Curr Opin Chem Biol. 2000 Oct;4(5):573-80. doi: 10.1016/s1367-5931(00)00135-6. Curr Opin Chem Biol. 2000. PMID: 11006547 Review.

4

Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.

Persson K, Ly HD, Dieckelmann M, Wakarchuk WW, Withers SG, Strynadka NC. Persson K, et al. Among authors: withers sg. Nat Struct Biol. 2001 Feb;8(2):166-75. doi: 10.1038/84168. Nat Struct Biol. 2001. PMID: 11175908

5

beta-Mannosynthase: Synthesis of beta-Mannosides with a Mutant beta-Mannosidase We thank the Protein Engineering Network of Centres of Excellence of Canada and the Natural Sciences and Engineering Research Council of Canada for support. D.L.Z. thanks the Izaak Walton Killam Foundation for a fellowship.

Nashiru O, Zechel DL, Stoll D, Mohammadzadeh T, Warren RA, Withers SG. Nashiru O, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2001 Jan 19;40(2):417-420. Angew Chem Int Ed Engl. 2001. PMID: 11180343 No abstract available.

6

Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.

Wrodnigg TM, Withers SG, Stütz AE. Wrodnigg TM, et al. Among authors: withers sg. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1063-4. doi: 10.1016/s0960-894x(01)00126-3. Bioorg Med Chem Lett. 2001. PMID: 11327590

7

Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.

Hermetter A, Scholze H, Stütz AE, Withers SG, Wrodnigg TM. Hermetter A, et al. Among authors: withers sg. Bioorg Med Chem Lett. 2001 May 21;11(10):1339-42. doi: 10.1016/s0960-894x(01)00209-8. Bioorg Med Chem Lett. 2001. PMID: 11392550

8

A structural view of the action of Escherichia coli (lacZ) beta-galactosidase.

Juers DH, Heightman TD, Vasella A, McCarter JD, Mackenzie L, Withers SG, Matthews BW. Juers DH, et al. Among authors: withers sg. Biochemistry. 2001 Dec 11;40(49):14781-94. doi: 10.1021/bi011727i. Biochemistry. 2001. PMID: 11732897

9

One step closer to a sweet conclusion.

Withers SG, Wakarchuk WW, Strynadka NC. Withers SG, et al. Chem Biol. 2002 Dec;9(12):1270-3. doi: 10.1016/s1074-5521(02)00291-0. Chem Biol. 2002. PMID: 12498879 Review.

10

Thioglycoligases: mutant glycosidases for thioglycoside synthesis.

Jahn M, Marles J, Warren RA, Withers SG. Jahn M, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2003 Jan 20;42(3):352-4. doi: 10.1002/anie.200390114. Angew Chem Int Ed Engl. 2003. PMID: 12548697 No abstract available.

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