Lacroix J - Search Results

1

Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.

Fortin JS, Lacroix J, Desjardins M, Patenaude A, Petitclerc E, C-Gaudreault R. Fortin JS, et al. Among authors: lacroix j. Bioorg Med Chem. 2007 Jul 1;15(13):4456-69. doi: 10.1016/j.bmc.2007.04.028. Epub 2007 Apr 22. Bioorg Med Chem. 2007. PMID: 17498960

2

A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.

Mounetou E, Legault J, Lacroix J, C -Gaudreault R. Mounetou E, et al. Among authors: lacroix j. J Med Chem. 2003 Nov 6;46(23):5055-63. doi: 10.1021/jm030908a. J Med Chem. 2003. PMID: 14584955

3

N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.

Fortin S, Moreau E, Patenaude A, Desjardins M, Lacroix J, Rousseau JL, C-Gaudreault R. Fortin S, et al. Among authors: lacroix j. Bioorg Med Chem. 2007 Feb 1;15(3):1430-8. doi: 10.1016/j.bmc.2006.11.005. Epub 2006 Nov 10. Bioorg Med Chem. 2007. PMID: 17118664 Free article.

4

N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

Fortin S, Moreau E, Lacroix J, Teulade JC, Patenaude A, C-Gaudreault R. Fortin S, et al. Among authors: lacroix j. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2000-4. doi: 10.1016/j.bmcl.2007.01.023. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17291753 Free article.

5

New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia.

Patenaude A, Deschesnes RG, Rousseau JL, Petitclerc E, Lacroix J, Côté MF, C-Gaudreault R. Patenaude A, et al. Among authors: lacroix j. Cancer Res. 2007 Mar 1;67(5):2306-16. doi: 10.1158/0008-5472.CAN-06-3824. Cancer Res. 2007. PMID: 17332362

6

N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: role of carbonyl groups in the covalent binding to the colchicine-binding site.

Moreau E, Fortin S, Lacroix J, Patenaude A, Rousseau JL, C-Gaudreault R. Moreau E, et al. Among authors: lacroix j. Bioorg Med Chem. 2008 Feb 1;16(3):1206-17. doi: 10.1016/j.bmc.2007.10.078. Epub 2007 Nov 12. Bioorg Med Chem. 2008. PMID: 17998163 Free article.

7

Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation.

Fortin JS, Côté MF, Lacroix J, Patenaude A, Petitclerc E, C-Gaudreault R. Fortin JS, et al. Among authors: lacroix j. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3526-31. doi: 10.1016/j.bmcl.2008.05.028. Epub 2008 May 10. Bioorg Med Chem Lett. 2008. PMID: 18502639

8

Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression.

Fortin JS, Côté MF, Lacroix J, Petitclerc E, C-Gaudreault R. Fortin JS, et al. Among authors: lacroix j. Bioorg Med Chem. 2008 Aug 1;16(15):7477-88. doi: 10.1016/j.bmc.2008.06.006. Epub 2008 Jun 10. Bioorg Med Chem. 2008. PMID: 18579387

9

Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents.

Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R. Fortin JS, et al. Among authors: lacroix j. Bioorg Med Chem. 2008 Aug 1;16(15):7277-90. doi: 10.1016/j.bmc.2008.06.028. Epub 2008 Jun 20. Bioorg Med Chem. 2008. PMID: 18617414

10

Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.

Fortin S, Moreau E, Lacroix J, Côté MF, Petitclerc E, C-Gaudreault R. Fortin S, et al. Among authors: lacroix j. Eur J Med Chem. 2010 Jul;45(7):2928-37. doi: 10.1016/j.ejmech.2010.03.018. Epub 2010 Mar 25. Eur J Med Chem. 2010. PMID: 20400211 Free article.

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