Sathasivam K - Search Results

1

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.

Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Kuhn A, et al. Among authors: sathasivam k. Hum Mol Genet. 2007 Aug 1;16(15):1845-61. doi: 10.1093/hmg/ddm133. Epub 2007 May 21. Hum Mol Genet. 2007. PMID: 17519223

2

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.

Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP. Mangiarini L, et al. Among authors: sathasivam k. Cell. 1996 Nov 1;87(3):493-506. doi: 10.1016/s0092-8674(00)81369-0. Cell. 1996. PMID: 8898202 Free article.

3

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

Mangiarini L, Sathasivam K, Mahal A, Mott R, Seller M, Bates GP. Mangiarini L, et al. Among authors: sathasivam k. Nat Genet. 1997 Feb;15(2):197-200. doi: 10.1038/ng0297-197. Nat Genet. 1997. PMID: 9020849

4

Identification of an HD patient with a (CAG)180 repeat expansion and the propagation of highly expanded CAG repeats in lambda phage.

Sathasivam K, Amaechi I, Mangiarini L, Bates G. Sathasivam K, et al. Hum Genet. 1997 May;99(5):692-5. doi: 10.1007/s004390050432. Hum Genet. 1997. PMID: 9150744

5

Aberrant processing of the Fugu HD (FrHD) mRNA in mouse cells and in transgenic mice.

Sathasivam K, Baxendale S, Mangiarini L, Bertaux F, Hetherington C, Kanazawa I, Lehrach H, Bates GP. Sathasivam K, et al. Hum Mol Genet. 1997 Nov;6(12):2141-9. doi: 10.1093/hmg/6.12.2141. Hum Mol Genet. 1997. PMID: 9328479

6

Formation of polyglutamine inclusions in non-CNS tissue.

Sathasivam K, Hobbs C, Turmaine M, Mangiarini L, Mahal A, Bertaux F, Wanker EE, Doherty P, Davies SW, Bates GP. Sathasivam K, et al. Hum Mol Genet. 1999 May;8(5):813-22. doi: 10.1093/hmg/8.5.813. Hum Mol Genet. 1999. PMID: 10196370

7

Transgenic models of Huntington's disease.

Sathasivam K, Hobbs C, Mangiarini L, Mahal A, Turmaine M, Doherty P, Davies SW, Bates GP. Sathasivam K, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):963-9. doi: 10.1098/rstb.1999.0447. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434294 Free PMC article. Review.

8

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

Waelter S, Scherzinger E, Hasenbank R, Nordhoff E, Lurz R, Goehler H, Gauss C, Sathasivam K, Bates GP, Lehrach H, Wanker EE. Waelter S, et al. Among authors: sathasivam k. Hum Mol Genet. 2001 Aug 15;10(17):1807-17. doi: 10.1093/hmg/10.17.1807. Hum Mol Genet. 2001. PMID: 11532990

9

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.

Sathasivam K, Woodman B, Mahal A, Bertaux F, Wanker EE, Shima DT, Bates GP. Sathasivam K, et al. Hum Mol Genet. 2001 Oct 1;10(21):2425-35. doi: 10.1093/hmg/10.21.2425. Hum Mol Genet. 2001. PMID: 11689489

10

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PA, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bates GP. Hockly E, et al. Among authors: sathasivam k. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6. doi: 10.1073/pnas.0437870100. Epub 2003 Feb 7. Proc Natl Acad Sci U S A. 2003. PMID: 12576549 Free PMC article.

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