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2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.
Kai H, Morioka Y, Murashi T, Morita K, Shinonome S, Nakazato H, Kawamoto K, Hanasaki K, Takahashi F, Mihara S, Arai T, Abe K, Okabe H, Baba T, Yoshikawa T, Takenaka H. Kai H, et al. Among authors: mihara s. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4030-4. doi: 10.1016/j.bmcl.2007.04.093. Epub 2007 Apr 30. Bioorg Med Chem Lett. 2007. PMID: 17521907
Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and basic structure crucial for ET(A) antagonism.
Ishizuka N, Matsumura K, Sakai K, Fujimoto M, Mihara S, Yamamori T. Ishizuka N, et al. Among authors: mihara s. J Med Chem. 2002 May 9;45(10):2041-55. doi: 10.1021/jm010382z. J Med Chem. 2002. PMID: 11985472
Chemoenzymatic synthesis of glycosylated glucagon-like peptide 1: effect of glycosylation on proteolytic resistance and in vivo blood glucose-lowering activity.
Ueda T, Tomita K, Notsu Y, Ito T, Fumoto M, Takakura T, Nagatome H, Takimoto A, Mihara S, Togame H, Kawamoto K, Iwasaki T, Asakura K, Oshima T, Hanasaki K, Nishimura S, Kondo H. Ueda T, et al. Among authors: mihara s. J Am Chem Soc. 2009 May 6;131(17):6237-45. doi: 10.1021/ja900261g. J Am Chem Soc. 2009. PMID: 19361194
242 results