Struthers RS - Search Results

1

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.

Chen M, Guo Z, Lanier MC, Zhao L, Betz SF, Huang CQ, Loweth CJ, Ashweek NJ, Liu XJ, Struthers RS, Bradbury MJ, Behan JW, Wen J, O'Brien Z, Saunders J, Zhu YF. Chen M, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3845-50. doi: 10.1016/j.bmcl.2007.05.009. Epub 2007 May 10. Bioorg Med Chem Lett. 2007. PMID: 17521908

2

Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.

Zhu YF, Struthers RS, Connors PJ Jr, Gao Y, Gross TD, Saunders J, Wilcoxen K, Reinhart GJ, Ling N, Chen C. Zhu YF, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2002 Feb 11;12(3):399-402. doi: 10.1016/s0960-894x(01)00779-x. Bioorg Med Chem Lett. 2002. PMID: 11814806

3

A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.

Zhu YF, Wilcoxen K, Saunders J, Guo Z, Gao Y, Connors PJ Jr, Gross TD, Tucci FC, Struthers RS, Reinhart GJ, Xie Q, Chen C. Zhu YF, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2002 Feb 11;12(3):403-6. doi: 10.1016/s0960-894x(01)00780-6. Bioorg Med Chem Lett. 2002. PMID: 11814807

4

Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

Wilcoxen KM, Zhu YF, Connors PJ, Saunders J, Gross TD, Gao Y, Reinhart GJ, Struthers RS, Chen C. Wilcoxen KM, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2179-83. doi: 10.1016/s0960-894x(02)00370-0. Bioorg Med Chem Lett. 2002. PMID: 12127532

5

Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

Gross TD, Zhu YF, Saunders J, Wilcoxen KM, Gao Y, Connors PJ Jr, Guo Z, Struthers RS, Reinhart GJ, Chen C. Gross TD, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2185-7. doi: 10.1016/s0960-894x(02)00371-2. Bioorg Med Chem Lett. 2002. PMID: 12127533

6

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists.

Tucci FC, Zhu YF, Guo Z, Gross TD, Connors PJ Jr, Struthers RS, Reinhart GJ, Wang X, Saunders J, Chen C. Tucci FC, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3491-5. doi: 10.1016/s0960-894x(02)00745-x. Bioorg Med Chem Lett. 2002. PMID: 12419391

7

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

Zhu YF, Guo Z, Gross TD, Gao Y, Connors PJ Jr, Struthers RS, Xie Q, Tucci FC, Reinhart GJ, Wu D, Saunders J, Chen C. Zhu YF, et al. Among authors: struthers rs. J Med Chem. 2003 Apr 24;46(9):1769-72. doi: 10.1021/jm0205402. J Med Chem. 2003. PMID: 12699396

8

Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.

Zhu YF, Gross TD, Guo Z, Connors PJ Jr, Gao Y, Tucci FC, Struthers RS, Reinhart GJ, Saunders J, Chen TK, Killam Bonneville AL, Chen C. Zhu YF, et al. Among authors: struthers rs. J Med Chem. 2003 May 22;46(11):2023-6. doi: 10.1021/jm034041s. J Med Chem. 2003. PMID: 12747774

9

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.

Guo Z, Zhu YF, Tucci FC, Gao Y, Struthers RS, Saunders J, Gross TD, Xie Q, Reinhart GJ, Chen C. Guo Z, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3311-5. doi: 10.1016/s0960-894x(03)00620-6. Bioorg Med Chem Lett. 2003. PMID: 12951116

10

Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.

Tucci FC, Zhu YF, Guo Z, Gross TD, Connors PJ Jr, Struthers RS, Reinhart GJ, Saunders J, Chen C. Tucci FC, et al. Among authors: struthers rs. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3317-22. doi: 10.1016/s0960-894x(03)00619-x. Bioorg Med Chem Lett. 2003. PMID: 12951117

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