Fiedler M - Search Results

1

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization.

Schwarz-Romond T, Fiedler M, Shibata N, Butler PJ, Kikuchi A, Higuchi Y, Bienz M. Schwarz-Romond T, et al. Among authors: fiedler m. Nat Struct Mol Biol. 2007 Jun;14(6):484-92. doi: 10.1038/nsmb1247. Epub 2007 May 27. Nat Struct Mol Biol. 2007. PMID: 17529994

2

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.

Fiedler M, Sánchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P, Bienz M. Fiedler M, et al. Mol Cell. 2008 May 23;30(4):507-18. doi: 10.1016/j.molcel.2008.03.011. Mol Cell. 2008. PMID: 18498752 Free PMC article.

3

Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.

Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M. Miller TC, et al. Among authors: fiedler m. J Mol Biol. 2010 Sep 3;401(5):969-84. doi: 10.1016/j.jmb.2010.07.007. Epub 2010 Jul 14. J Mol Biol. 2010. PMID: 20637214 Free PMC article.

4

Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.

Metcalfe C, Ibrahim AE, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A, Bienz M. Metcalfe C, et al. Among authors: fiedler m. Cancer Res. 2010 Aug 15;70(16):6629-38. doi: 10.1158/0008-5472.CAN-10-1616. Epub 2010 Jul 27. Cancer Res. 2010. PMID: 20663899 Free PMC article.

5

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin.

Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczanek J, Bienz M. Fiedler M, et al. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1937-42. doi: 10.1073/pnas.1017063108. Epub 2011 Jan 18. Proc Natl Acad Sci U S A. 2011. PMID: 21245303 Free PMC article.

6

Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2.

Miller TC, Mieszczanek J, Sánchez-Barrena MJ, Rutherford TJ, Fiedler M, Bienz M. Miller TC, et al. Among authors: fiedler m. Structure. 2013 Dec 3;21(12):2208-20. doi: 10.1016/j.str.2013.09.013. Epub 2013 Oct 31. Structure. 2013. PMID: 24183574 Free PMC article.

7

Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.

Miller TC, Rutherford TJ, Birchall K, Chugh J, Fiedler M, Bienz M. Miller TC, et al. Among authors: fiedler m. ACS Chem Biol. 2014 Dec 19;9(12):2864-74. doi: 10.1021/cb500585s. Epub 2014 Oct 24. ACS Chem Biol. 2014. PMID: 25323450 Free PMC article.

8

Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.

Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW. Madrzak J, et al. Among authors: fiedler m. Nat Commun. 2015 Apr 24;6:6718. doi: 10.1038/ncomms7718. Nat Commun. 2015. PMID: 25907794 Free PMC article.

9

An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.

Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M. Fiedler M, et al. Elife. 2015 Aug 27;4:e09073. doi: 10.7554/eLife.09073. Elife. 2015. PMID: 26312500 Free PMC article.

10

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

van Tienen LM, Mieszczanek J, Fiedler M, Rutherford TJ, Bienz M. van Tienen LM, et al. Among authors: fiedler m. Elife. 2017 Mar 15;6:e20882. doi: 10.7554/eLife.20882. Elife. 2017. PMID: 28296634 Free PMC article.

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