Margosiak S - Search Results

1

Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2.

Nie Z, Perretta C, Erickson P, Margosiak S, Almassy R, Lu J, Averill A, Yager KM, Chu S. Nie Z, et al. Among authors: margosiak s. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4191-5. doi: 10.1016/j.bmcl.2007.05.041. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17540560

2

Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors.

Li X, Chu S, Feher VA, Khalili M, Nie Z, Margosiak S, Nikulin V, Levin J, Sprankle KG, Tedder ME, Almassy R, Appelt K, Yager KM. Li X, et al. Among authors: margosiak s. J Med Chem. 2003 Dec 18;46(26):5663-73. doi: 10.1021/jm0302039. J Med Chem. 2003. PMID: 14667220

3

Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors.

Tedder ME, Nie Z, Margosiak S, Chu S, Feher VA, Almassy R, Appelt K, Yager KM. Tedder ME, et al. Among authors: margosiak s. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3165-8. doi: 10.1016/j.bmcl.2004.04.006. Bioorg Med Chem Lett. 2004. PMID: 15149667

4

Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.

Nie Z, Perretta C, Lu J, Su Y, Margosiak S, Gajiwala KS, Cortez J, Nikulin V, Yager KM, Appelt K, Chu S. Nie Z, et al. Among authors: margosiak s. J Med Chem. 2005 Mar 10;48(5):1596-609. doi: 10.1021/jm049141s. J Med Chem. 2005. PMID: 15743201

5

Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities.

Nie Z, Perretta C, Erickson P, Margosiak S, Lu J, Averill A, Almassy R, Chu S. Nie Z, et al. Among authors: margosiak s. Bioorg Med Chem Lett. 2008 Jan 15;18(2):619-23. doi: 10.1016/j.bmcl.2007.11.074. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18055206

6

Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.

Varney MD, Palmer CL, Romines WH 3rd, Boritzki T, Margosiak SA, Almassy R, Janson CA, Bartlett C, Howland EJ, Ferre R. Varney MD, et al. Among authors: margosiak sa. J Med Chem. 1997 Aug 1;40(16):2502-24. doi: 10.1021/jm9607459. J Med Chem. 1997. PMID: 9258357

7

Structure-based design of novel human Pin1 inhibitors (I).

Guo C, Hou X, Dong L, Dagostino E, Greasley S, Ferre R, Marakovits J, Johnson MC, Matthews D, Mroczkowski B, Parge H, Vanarsdale T, Popoff I, Piraino J, Margosiak S, Thomson J, Los G, Murray BW. Guo C, et al. Among authors: margosiak s. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5613-6. doi: 10.1016/j.bmcl.2009.08.034. Epub 2009 Aug 13. Bioorg Med Chem Lett. 2009. PMID: 19729306

8

Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.

Gajiwala KS, Margosiak S, Lu J, Cortez J, Su Y, Nie Z, Appelt K. Gajiwala KS, et al. Among authors: margosiak s. FEBS Lett. 2009 Sep 3;583(17):2939-46. doi: 10.1016/j.febslet.2009.08.001. Epub 2009 Aug 6. FEBS Lett. 2009. PMID: 19665020 Free article.

9

Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad.

Chen P, Tsuge H, Almassy RJ, Gribskov CL, Katoh S, Vanderpool DL, Margosiak SA, Pinko C, Matthews DA, Kan CC. Chen P, et al. Among authors: margosiak sa. Cell. 1996 Sep 6;86(5):835-43. doi: 10.1016/s0092-8674(00)80157-9. Cell. 1996. PMID: 8797829 Free article.

10

Virtual medicinal chemistry: in silico pre-docking functional group transformation for discovery of novel inhibitors of botulinum toxin serotype A light chain.

O'Malley S, Sareth S, Jiao GS, Kim S, Thai A, Cregar-Hernandez L, McKasson L, Margosiak SA, Johnson AT. O'Malley S, et al. Among authors: margosiak sa. Bioorg Med Chem Lett. 2013 May 1;23(9):2505-11. doi: 10.1016/j.bmcl.2013.03.030. Epub 2013 Mar 18. Bioorg Med Chem Lett. 2013. PMID: 23545109

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