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A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
Pasvolsky R, Feigelson SW, Kilic SS, Simon AJ, Tal-Lapidot G, Grabovsky V, Crittenden JR, Amariglio N, Safran M, Graybiel AM, Rechavi G, Ben-Dor S, Etzioni A, Alon R. Pasvolsky R, et al. Among authors: grabovsky v. J Exp Med. 2007 Jul 9;204(7):1571-82. doi: 10.1084/jem.20070058. Epub 2007 Jun 18. J Exp Med. 2007. PMID: 17576779 Free PMC article.
Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.
Manevich-Mendelson E, Feigelson SW, Pasvolsky R, Aker M, Grabovsky V, Shulman Z, Kilic SS, Rosenthal-Allieri MA, Ben-Dor S, Mory A, Bernard A, Moser M, Etzioni A, Alon R. Manevich-Mendelson E, et al. Among authors: grabovsky v. Blood. 2009 Sep 10;114(11):2344-53. doi: 10.1182/blood-2009-04-218636. Epub 2009 Jul 17. Blood. 2009. PMID: 19617577 Free article.
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.
Alon R, Aker M, Feigelson S, Sokolovsky-Eisenberg M, Staunton DE, Cinamon G, Grabovsky V, Shamri R, Etzioni A. Alon R, et al. Among authors: grabovsky v. Blood. 2003 Jun 1;101(11):4437-45. doi: 10.1182/blood-2002-11-3427. Epub 2003 Feb 20. Blood. 2003. PMID: 12595312 Free article.
54 results