Ai N - Search Results

1

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.

Ekins S, Chang C, Mani S, Krasowski MD, Reschly EJ, Iyer M, Kholodovych V, Ai N, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachmann K. Ekins S, et al. Among authors: ai n. Mol Pharmacol. 2007 Sep;72(3):592-603. doi: 10.1124/mol.107.038398. Epub 2007 Jun 18. Mol Pharmacol. 2007. PMID: 17576789

2

Computational discovery of novel low micromolar human pregnane X receptor antagonists.

Ekins S, Kholodovych V, Ai N, Sinz M, Gal J, Gera L, Welsh WJ, Bachmann K, Mani S. Ekins S, et al. Among authors: ai n. Mol Pharmacol. 2008 Sep;74(3):662-72. doi: 10.1124/mol.108.049437. Epub 2008 Jun 25. Mol Pharmacol. 2008. PMID: 18579710

3

Evolution of the bile salt nuclear receptor FXR in vertebrates.

Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann AF, Krasowski MD. Reschly EJ, et al. Among authors: ai n. J Lipid Res. 2008 Jul;49(7):1577-87. doi: 10.1194/jlr.M800138-JLR200. Epub 2008 Mar 24. J Lipid Res. 2008. PMID: 18362391 Free PMC article.

4

Ligand specificity and evolution of liver X receptors.

Reschly EJ, Ai N, Welsh WJ, Ekins S, Hagey LR, Krasowski MD. Reschly EJ, et al. Among authors: ai n. J Steroid Biochem Mol Biol. 2008 May;110(1-2):83-94. doi: 10.1016/j.jsbmb.2008.02.007. Epub 2008 Mar 10. J Steroid Biochem Mol Biol. 2008. PMID: 18395439 Free PMC article.

5

The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.

Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG. Lin YS, et al. Among authors: ai n. Drug Metab Dispos. 2009 Jun;37(6):1295-304. doi: 10.1124/dmd.108.025213. Epub 2009 Feb 27. Drug Metab Dispos. 2009. PMID: 19251824 Free PMC article.

6

Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.

Helsley RN, Sui Y, Ai N, Park SH, Welsh WJ, Zhou C. Helsley RN, et al. Among authors: ai n. Mol Pharmacol. 2013 Jun;83(6):1190-9. doi: 10.1124/mol.113.085753. Epub 2013 Mar 21. Mol Pharmacol. 2013. PMID: 23519392 Free PMC article.

7

In silico methods for predicting drug-drug interactions with cytochrome P-450s, transporters and beyond.

Ai N, Fan X, Ekins S. Ai N, et al. Adv Drug Deliv Rev. 2015 Jun 23;86:46-60. doi: 10.1016/j.addr.2015.03.006. Epub 2015 Mar 19. Adv Drug Deliv Rev. 2015. PMID: 25796619 Review.

8

The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.

Krasowski MD, Ai N, Hagey LR, Kollitz EM, Kullman SW, Reschly EJ, Ekins S. Krasowski MD, et al. Among authors: ai n. BMC Biochem. 2011 Feb 3;12:5. doi: 10.1186/1471-2091-12-5. BMC Biochem. 2011. PMID: 21291553 Free PMC article.

9

Bisphenol A and its analogues activate human pregnane X receptor.

Sui Y, Ai N, Park SH, Rios-Pilier J, Perkins JT, Welsh WJ, Zhou C. Sui Y, et al. Among authors: ai n. Environ Health Perspect. 2012 Mar;120(3):399-405. doi: 10.1289/ehp.1104426. Epub 2012 Jan 3. Environ Health Perspect. 2012. PMID: 22214767 Free PMC article.

10

Understanding nuclear receptors using computational methods.

Ai N, Krasowski MD, Welsh WJ, Ekins S. Ai N, et al. Drug Discov Today. 2009 May;14(9-10):486-94. doi: 10.1016/j.drudis.2009.03.003. Epub 2009 Mar 11. Drug Discov Today. 2009. PMID: 19429508 Free PMC article. Review.

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