Hutton CA - Search Results

1

Inhibition of lysine biosynthesis: an evolving antibiotic strategy.

Hutton CA, Perugini MA, Gerrard JA. Hutton CA, et al. Mol Biosyst. 2007 Jul;3(7):458-65. doi: 10.1039/b705624a. Epub 2007 May 23. Mol Biosyst. 2007. PMID: 17579770 Review.

2

Inhibitors of lysine biosynthesis as antibacterial agents.

Hutton CA, Southwood TJ, Turner JJ. Hutton CA, et al. Mini Rev Med Chem. 2003 Mar;3(2):115-27. doi: 10.2174/1389557033405359. Mini Rev Med Chem. 2003. PMID: 12570844 Review.

3

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

Turner JJ, Healy JP, Dobson RC, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: hutton ca. Bioorg Med Chem Lett. 2005 Feb 15;15(4):995-8. doi: 10.1016/j.bmcl.2004.12.043. Bioorg Med Chem Lett. 2005. PMID: 15686899

4

Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.

Turner JJ, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: hutton ca. Bioorg Med Chem. 2005 Mar 15;13(6):2133-40. doi: 10.1016/j.bmc.2005.01.001. Bioorg Med Chem. 2005. PMID: 15727866

5

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

Gerrard JA, Hutton CA, Perugini MA. Gerrard JA, et al. Among authors: hutton ca. Mini Rev Med Chem. 2007 Feb;7(2):151-7. doi: 10.2174/138955707779802561. Mini Rev Med Chem. 2007. PMID: 17305589 Review.

6

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

Mitsakos V, Dobson RC, Pearce FG, Devenish SR, Evans GL, Burgess BR, Perugini MA, Gerrard JA, Hutton CA. Mitsakos V, et al. Among authors: hutton ca. Bioorg Med Chem Lett. 2008 Jan 15;18(2):842-4. doi: 10.1016/j.bmcl.2007.11.026. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18054225

7

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

Boughton BA, Dobson RC, Gerrard JA, Hutton CA. Boughton BA, et al. Among authors: hutton ca. Bioorg Med Chem Lett. 2008 Jan 15;18(2):460-3. doi: 10.1016/j.bmcl.2007.11.108. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18077163

8

Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.

Dobson RC, Griffin MD, Devenish SR, Pearce FG, Hutton CA, Gerrard JA, Jameson GB, Perugini MA. Dobson RC, et al. Among authors: hutton ca. Protein Sci. 2008 Dec;17(12):2080-90. doi: 10.1110/ps.037440.108. Epub 2008 Sep 11. Protein Sci. 2008. PMID: 18787203 Free PMC article.

9

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.

Boughton BA, Griffin MD, O'Donnell PA, Dobson RC, Perugini MA, Gerrard JA, Hutton CA. Boughton BA, et al. Among authors: hutton ca. Bioorg Med Chem. 2008 Dec 1;16(23):9975-83. doi: 10.1016/j.bmc.2008.10.026. Epub 2008 Oct 17. Bioorg Med Chem. 2008. PMID: 18977662

10

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate.

Voss JE, Scally SW, Taylor NL, Dogovski C, Alderton MR, Hutton CA, Gerrard JA, Parker MW, Dobson RC, Perugini MA. Voss JE, et al. Among authors: hutton ca. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):188-91. doi: 10.1107/S1744309109000670. Epub 2009 Jan 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19194017 Free PMC article.

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