Zhang YK - Search Results

1

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR. Rock FL, et al. Among authors: zhang yk. Science. 2007 Jun 22;316(5832):1759-61. doi: 10.1126/science.1142189. Science. 2007. PMID: 17588934

2

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

Baker SJ, Zhang YK, Akama T, Lau A, Zhou H, Hernandez V, Mao W, Alley MR, Sanders V, Plattner JJ. Baker SJ, et al. Among authors: zhang yk. J Med Chem. 2006 Jul 27;49(15):4447-50. doi: 10.1021/jm0603724. J Med Chem. 2006. PMID: 16854048

3

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases.

Baker SJ, Akama T, Zhang YK, Sauro V, Pandit C, Singh R, Kully M, Khan J, Plattner JJ, Benkovic SJ, Lee V, Maples KR. Baker SJ, et al. Among authors: zhang yk. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5963-7. doi: 10.1016/j.bmcl.2006.08.130. Epub 2006 Sep 25. Bioorg Med Chem Lett. 2006. PMID: 16997550

4

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Akama T, Baker SJ, Zhang YK, Hernandez V, Zhou H, Sanders V, Freund Y, Kimura R, Maples KR, Plattner JJ. Akama T, et al. Among authors: zhang yk. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32. doi: 10.1016/j.bmcl.2009.03.007. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19303290

5

Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.

Zhang YK, Plattner JJ, Akama T, Baker SJ, Hernandez VS, Sanders V, Freund Y, Kimura R, Bu W, Hold KM, Lu XS. Zhang YK, et al. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2270-4. doi: 10.1016/j.bmcl.2010.02.010. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20188549

6

Therapeutic potential of boron-containing compounds.

Baker SJ, Ding CZ, Akama T, Zhang YK, Hernandez V, Xia Y. Baker SJ, et al. Among authors: zhang yk. Future Med Chem. 2009 Oct;1(7):1275-88. doi: 10.4155/fmc.09.71. Future Med Chem. 2009. PMID: 21426103 Review.

7

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Ye L, Zhou H, Waterson D, Gamo FJ, Sanz LM, Ge M, Li Z, Li L, Wang H, Cui H. Zhang YK, et al. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1299-307. doi: 10.1016/j.bmcl.2011.12.096. Epub 2011 Dec 28. Bioorg Med Chem Lett. 2012. PMID: 22243961

8

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. Hernandez V, et al. Among authors: zhang yk, zhang y. Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7. Antimicrob Agents Chemother. 2013. PMID: 23295920 Free PMC article.

9

Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone.

Li X, Zhang YK, Plattner JJ, Mao W, Alley MR, Xia Y, Hernandez V, Zhou Y, Ding CZ, Li J, Shao Z, Zhang H, Xu M. Li X, et al. Among authors: zhang yk, zhang h. Bioorg Med Chem Lett. 2013 Feb 15;23(4):963-6. doi: 10.1016/j.bmcl.2012.12.045. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23312945

10

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ. Sonoiki E, et al. Among authors: zhang yk. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug. Antimicrob Agents Chemother. 2016. PMID: 27270277 Free PMC article.

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