Mutlib AE - Search Results

1

Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.

Milbank JB, Knauer CS, Augelli-Szafran CE, Sakkab-Tan AT, Lin KK, Yamagata K, Hoffman JK, Zhuang N, Thomas J, Galatsis P, Wendt JA, Mickelson JW, Schwarz RD, Kinsora JJ, Lotarski SM, Stakich K, Gillespie KK, Lam WW, Mutlib AE. Milbank JB, et al. Among authors: mutlib ae. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. doi: 10.1016/j.bmcl.2007.06.030. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17590335

2

Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites.

Mutlib A, Lam W, Atherton J, Chen H, Galatsis P, Stolle W. Mutlib A, et al. Rapid Commun Mass Spectrom. 2005;19(23):3482-92. doi: 10.1002/rcm.2223. Rapid Commun Mass Spectrom. 2005. PMID: 16261644

3

Application of in-line liquid chromatography-accurate radioisotope counting-mass spectrometry (LC-ARC-MS) to evaluate metabolic profile of [3H]-mefenamic acid in rat plasma.

Lam W, Loi CM, Atherton J, Stolle W, Easter J, Mutlib A. Lam W, et al. Drug Metab Lett. 2007 Aug;1(3):179-88. doi: 10.2174/187231207781369771. Drug Metab Lett. 2007. PMID: 19356041

4

Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.

Walker GS, Atherton J, Bauman J, Kohl C, Lam W, Reily M, Lou Z, Mutlib A. Walker GS, et al. Chem Res Toxicol. 2007 Jun;20(6):876-86. doi: 10.1021/tx600297u. Epub 2007 May 31. Chem Res Toxicol. 2007. PMID: 17536843

5

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL. Kalgutkar AS, et al. Among authors: mutlib ae. Chem Res Toxicol. 2007 Dec;20(12):1954-65. doi: 10.1021/tx700270r. Epub 2007 Oct 13. Chem Res Toxicol. 2007. PMID: 17935300

6

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.

Markwalder JA, Christ DD, Mutlib A, Cordova BC, Klabe RM, Seitz SP. Markwalder JA, et al. Bioorg Med Chem Lett. 2001 Mar 12;11(5):619-22. doi: 10.1016/s0960-894x(01)00012-9. Bioorg Med Chem Lett. 2001. PMID: 11266155

7

Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.

Chen H, Zhang Y, Edmunds J, Bigge C, Mutlib A. Chen H, et al. Chem Res Toxicol. 2008 May;21(5):1095-106. doi: 10.1021/tx7004019. Epub 2008 Apr 5. Chem Res Toxicol. 2008. PMID: 18393453

8

Metabolism-dependent mutagenicity of a compound containing a piperazinyl indazole motif: Role of a novel p450-mediated metabolic reaction involving a putative oxaziridine intermediate.

Chen H, Murray J, Kornberg B, Dethloff L, Rock D, Nikam S, Mutlib AE. Chen H, et al. Among authors: mutlib ae. Chem Res Toxicol. 2006 Oct;19(10):1341-50. doi: 10.1021/tx050354+. Chem Res Toxicol. 2006. PMID: 17040103

9

Application of on-line electrochemical derivatization coupled with high-performance liquid chromatography electrospray ionization mass spectrometry for detection and quantitation of (p-chlorophenyl)aniline in biological samples.

Chen H, Zhang Y, Mutlib AE, Zhong M. Chen H, et al. Among authors: mutlib ae. Anal Chem. 2006 Apr 1;78(7):2413-21. doi: 10.1021/ac051949c. Anal Chem. 2006. PMID: 16579628

10

Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes.

Kostrubsky SE, Sinclair JF, Strom SC, Wood S, Urda E, Stolz DB, Wen YH, Kulkarni S, Mutlib A. Kostrubsky SE, et al. Toxicol Sci. 2005 Sep;87(1):146-55. doi: 10.1093/toxsci/kfi211. Epub 2005 Jun 2. Toxicol Sci. 2005. PMID: 15933229

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