Leamon CP - Search Results

1

An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.

Vlahov IR, Santhapuram HK, Wang Y, Kleindl PJ, You F, Howard SJ, Westrick E, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. J Org Chem. 2007 Aug 3;72(16):5968-72. doi: 10.1021/jo070411z. Epub 2007 Jun 29. J Org Chem. 2007. PMID: 17602528

2

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide.

Vlahov IR, Santhapuram HK, Kleindl PJ, Howard SJ, Stanford KM, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5093-6. doi: 10.1016/j.bmcl.2006.07.030. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870437

3

Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate.

Leamon CP, Reddy JA, Vlahov IR, Kleindl PJ, Vetzel M, Westrick E. Leamon CP, et al. Bioconjug Chem. 2006 Sep-Oct;17(5):1226-32. doi: 10.1021/bc060145g. Bioconjug Chem. 2006. PMID: 16984132

4

Preclinical antitumor activity of a novel folate-targeted dual drug conjugate.

Leamon CP, Reddy JA, Vlahov IR, Westrick E, Dawson A, Dorton R, Vetzel M, Santhapuram HK, Wang Y. Leamon CP, et al. Mol Pharm. 2007 Sep-Oct;4(5):659-67. doi: 10.1021/mp070049c. Epub 2007 Sep 18. Mol Pharm. 2007. PMID: 17874843

5

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides.

Vlahov IR, Wang Y, Kleindl PJ, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4558-61. doi: 10.1016/j.bmcl.2008.07.041. Epub 2008 Jul 15. Bioorg Med Chem Lett. 2008. PMID: 18657420

6

Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.

Vlahov IR, Santhapuram HK, You F, Wang Y, Kleindl PJ, Hahn SJ, Vaughn JF, Reno DS, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. J Org Chem. 2010 Jun 4;75(11):3685-91. doi: 10.1021/jo100448q. J Org Chem. 2010. PMID: 20423159

7

Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.

Vlahov IR, Vite GD, Kleindl PJ, Wang Y, Santhapuram HK, You F, Howard SJ, Kim SH, Lee FF, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4578-81. doi: 10.1016/j.bmcl.2010.06.016. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20594844

8

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.

Vlahov IR, You F, Santhapuram HK, Wang Y, Vaughn JF, Hahn SJ, Kleindl PJ, Fan M, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1202-5. doi: 10.1016/j.bmcl.2010.12.085. Epub 2010 Dec 22. Bioorg Med Chem Lett. 2011. PMID: 21236665

9

Engineering folate-drug conjugates to target cancer: from chemistry to clinic.

Vlahov IR, Leamon CP. Vlahov IR, et al. Among authors: leamon cp. Bioconjug Chem. 2012 Jul 18;23(7):1357-69. doi: 10.1021/bc2005522. Epub 2012 Jun 26. Bioconjug Chem. 2012. PMID: 22667324 Review.

10

Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

Leamon CP, Vlahov IR, Reddy JA, Vetzel M, Santhapuram HK, You F, Bloomfield A, Dorton R, Nelson M, Kleindl P, Vaughn JF, Westrick E. Leamon CP, et al. Bioconjug Chem. 2014 Mar 19;25(3):560-8. doi: 10.1021/bc400441s. Epub 2014 Mar 11. Bioconjug Chem. 2014. PMID: 24564229

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