You F - Search Results

1

An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.

Vlahov IR, Santhapuram HK, Wang Y, Kleindl PJ, You F, Howard SJ, Westrick E, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: you f. J Org Chem. 2007 Aug 3;72(16):5968-72. doi: 10.1021/jo070411z. Epub 2007 Jun 29. J Org Chem. 2007. PMID: 17602528

2

Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.

Vlahov IR, Santhapuram HK, You F, Wang Y, Kleindl PJ, Hahn SJ, Vaughn JF, Reno DS, Leamon CP. Vlahov IR, et al. Among authors: you f. J Org Chem. 2010 Jun 4;75(11):3685-91. doi: 10.1021/jo100448q. J Org Chem. 2010. PMID: 20423159

3

Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.

Vlahov IR, Vite GD, Kleindl PJ, Wang Y, Santhapuram HK, You F, Howard SJ, Kim SH, Lee FF, Leamon CP. Vlahov IR, et al. Among authors: you f. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4578-81. doi: 10.1016/j.bmcl.2010.06.016. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20594844

4

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.

Vlahov IR, You F, Santhapuram HK, Wang Y, Vaughn JF, Hahn SJ, Kleindl PJ, Fan M, Leamon CP. Vlahov IR, et al. Among authors: you f. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1202-5. doi: 10.1016/j.bmcl.2010.12.085. Epub 2010 Dec 22. Bioorg Med Chem Lett. 2011. PMID: 21236665

5

Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

Leamon CP, Vlahov IR, Reddy JA, Vetzel M, Santhapuram HK, You F, Bloomfield A, Dorton R, Nelson M, Kleindl P, Vaughn JF, Westrick E. Leamon CP, et al. Among authors: you f. Bioconjug Chem. 2014 Mar 19;25(3):560-8. doi: 10.1021/bc400441s. Epub 2014 Mar 11. Bioconjug Chem. 2014. PMID: 24564229

6

Folate-targeted dinitrophenyl hapten immunotherapy: effect of linker chemistry on antitumor activity and allergic potential.

Lu Y, You F, Vlahov I, Westrick E, Fan M, Low PS, Leamon CP. Lu Y, et al. Among authors: you f. Mol Pharm. 2007 Sep-Oct;4(5):695-706. doi: 10.1021/mp070050b. Epub 2007 Sep 5. Mol Pharm. 2007. PMID: 17784727

7

Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor.

Leamon CP, You F, Santhapuram HK, Fan M, Vlahov IR. Leamon CP, et al. Among authors: you f. Pharm Res. 2009 Jun;26(6):1315-23. doi: 10.1007/s11095-009-9840-3. Epub 2009 Feb 3. Pharm Res. 2009. PMID: 19189203

8

Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus.

Lu Y, Parker N, Kleindl PJ, Cross VA, Wollak K, Westrick E, Stinnette TW, Gehrke MA, Wang K, Santhapuram HK, You F, Hahn SJ, Vaughn JF, Klein PJ, Vlahov IR, Low PS, Leamon CP. Lu Y, et al. Among authors: you f. Mol Med. 2015 Jul 8;21(1):584-96. doi: 10.2119/molmed.2015.00040. Mol Med. 2015. PMID: 26181632 Free PMC article.

9

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.

Vlahov IR, Qi L, Kleindl PJ, Santhapuram HK, Felten A, Parham GL, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Vetzel M, Reddy JA, Nelson M, Nicoson J, Leamon CP. Vlahov IR, et al. Among authors: you f. Bioconjug Chem. 2017 Dec 20;28(12):2921-2931. doi: 10.1021/acs.bioconjchem.7b00476. Epub 2017 Dec 6. Bioconjug Chem. 2017. PMID: 29211454

10

Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate.

Vlahov IR, Qi L, Santhapuram HKR, Felten A, Parham GL, Zou N, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Kleindl PJ, Reddy J, Reno D, Nicoson J, Leamon CP. Vlahov IR, et al. Among authors: you f. Bioorg Med Chem Lett. 2020 Apr 1;30(7):126987. doi: 10.1016/j.bmcl.2020.126987. Epub 2020 Jan 27. Bioorg Med Chem Lett. 2020. PMID: 32029324

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