Lovering F - Search Results

1

Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.

Huang A, Joseph-McCarthy D, Lovering F, Sun L, Wang W, Xu W, Zhu Y, Cui J, Zhang Y, Levin JI. Huang A, et al. Among authors: lovering f. Bioorg Med Chem. 2007 Sep 15;15(18):6170-81. doi: 10.1016/j.bmc.2007.06.031. Epub 2007 Jun 20. Bioorg Med Chem. 2007. PMID: 17606376

2

Therapeutic potential of TACE inhibitors in stroke.

Lovering F, Zhang Y. Lovering F, et al. Curr Drug Targets CNS Neurol Disord. 2005 Apr;4(2):161-8. doi: 10.2174/1568007053544147. Curr Drug Targets CNS Neurol Disord. 2005. PMID: 15857301 Review.

3

Identification of potent and selective MMP-13 inhibitors.

Wu J, Rush TS 3rd, Hotchandani R, Du X, Geck M, Collins E, Xu ZB, Skotnicki J, Levin JI, Lovering FE. Wu J, et al. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4105-9. doi: 10.1016/j.bmcl.2005.06.019. Bioorg Med Chem Lett. 2005. PMID: 16005220

4

Identification of potent and selective TACE inhibitors via the S1 pocket.

Condon JS, Joseph-McCarthy D, Levin JI, Lombart HG, Lovering FE, Sun L, Wang W, Xu W, Zhang Y. Condon JS, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):34-9. doi: 10.1016/j.bmcl.2006.10.004. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17064892

5

Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

McKew JC, Lovering F, Clark JD, Bemis J, Xiang Y, Shen M, Zhang W, Alvarez JC, Joseph-McCarthy D. McKew JC, et al. Among authors: lovering f. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4501-4. doi: 10.1016/j.bmcl.2003.08.070. Bioorg Med Chem Lett. 2003. PMID: 14643356

6

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Joseph-McCarthy D, et al. Among authors: lovering f. J Med Chem. 2005 Dec 15;48(25):7960-9. doi: 10.1021/jm050523n. J Med Chem. 2005. PMID: 16335920

7

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.

Lombart HG, Feyfant E, Joseph-McCarthy D, Huang A, Lovering F, Sun L, Zhu Y, Zeng C, Zhang Y, Levin J. Lombart HG, et al. Among authors: lovering f. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4333-7. doi: 10.1016/j.bmcl.2007.05.022. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17531482

8

Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.

Zhang C, Lovering F, Behnke M, Zask A, Sandanayaka V, Sun L, Zhu Y, Xu W, Zhang Y, Levin JI. Zhang C, et al. Among authors: lovering f. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3445-8. doi: 10.1016/j.bmcl.2009.05.020. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19464885

9

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

Lovering F, Kirincich S, Wang W, Combs K, Resnick L, Sabalski JE, Butera J, Liu J, Parris K, Telliez JB. Lovering F, et al. Bioorg Med Chem. 2009 May 1;17(9):3342-51. doi: 10.1016/j.bmc.2009.03.041. Epub 2009 Mar 26. Bioorg Med Chem. 2009. PMID: 19364658

10

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.

Lee KL, Foley MA, Chen L, Behnke ML, Lovering FE, Kirincich SJ, Wang W, Shim J, Tam S, Shen MW, Khor S, Xu X, Goodwin DG, Ramarao MK, Nickerson-Nutter C, Donahue F, Ku MS, Clark JD, McKew JC. Lee KL, et al. Among authors: lovering fe. J Med Chem. 2007 Mar 22;50(6):1380-400. doi: 10.1021/jm061131z. Epub 2007 Feb 17. J Med Chem. 2007. PMID: 17305324

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