Njoroge FG - Search Results

1

Application of ring-closing metathesis for the synthesis of macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.

Velázquez F, Venkatraman S, Wu W, Blackman M, Prongay A, Girijavallabhan V, Shih NY, Njoroge FG. Velázquez F, et al. Among authors: njoroge fg. Org Lett. 2007 Aug 2;9(16):3061-4. doi: 10.1021/ol0711265. Epub 2007 Jul 4. Org Lett. 2007. PMID: 17608487

2

A convenient synthesis of cis and trans 4-tert-butoxycarbonyl-substituted cyclohexylglycine.

Venkatraman S, Njoroge FG, Girijavallabhan V, McPhail AT. Venkatraman S, et al. Among authors: njoroge fg. J Org Chem. 2002 Apr 19;67(8):2686-8. doi: 10.1021/jo010512b. J Org Chem. 2002. PMID: 11950318

3

Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides.

Venkatraman S, Njoroge FG, Girijavallabhan V, McPhail AT. Venkatraman S, et al. Among authors: njoroge fg. J Org Chem. 2002 May 3;67(9):3152-5. doi: 10.1021/jo011106v. J Org Chem. 2002. PMID: 11975586

4

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.

Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Arasappan A, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. doi: 10.1016/j.bmcl.2004.09.058. Bioorg Med Chem Lett. 2004. PMID: 15501035

5

Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.

Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: njoroge fg. J Med Chem. 2005 Aug 11;48(16):5088-91. doi: 10.1021/jm0489556. J Med Chem. 2005. PMID: 16078825

6

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.

Chen KX, Njoroge FG, Prongay A, Pichardo J, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4475-8. doi: 10.1016/j.bmcl.2005.07.033. Bioorg Med Chem Lett. 2005. PMID: 16112859

7

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. J Med Chem. 2005 Oct 6;48(20):6229-35. doi: 10.1021/jm050323b. J Med Chem. 2005. PMID: 16190750

8

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. doi: 10.1016/j.bmcl.2005.12.013. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387495

9

Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.

Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. doi: 10.1016/j.bmcl.2005.12.046. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413182

10

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: njoroge fg. J Med Chem. 2006 Jan 26;49(2):567-74. doi: 10.1021/jm050520a. J Med Chem. 2006. PMID: 16420042

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