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Page 1
Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.
Combrink KD, Gulgeze HB, Thuring JW, Yu KL, Civiello RL, Zhang Y, Pearce BC, Yin Z, Langley DR, Kadow KF, Cianci CW, Li Z, Clarke J, Genovesi EV, Medina I, Lamb L, Yang Z, Zadjura L, Krystal M, Meanwell NA. Combrink KD, et al. Among authors: gulgeze hb. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4784-90. doi: 10.1016/j.bmcl.2007.06.065. Epub 2007 Jun 26. Bioorg Med Chem Lett. 2007. PMID: 17616396
Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.
Yu KL, Zhang Y, Civiello RL, Trehan AK, Pearce BC, Yin Z, Combrink KD, Gulgeze HB, Wang XA, Kadow KF, Cianci CW, Krystal M, Meanwell NA. Yu KL, et al. Among authors: gulgeze hb. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1133-7. doi: 10.1016/j.bmcl.2003.12.072. Bioorg Med Chem Lett. 2004. PMID: 14980651
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo.
Yu KL, Wang XA, Civiello RL, Trehan AK, Pearce BC, Yin Z, Combrink KD, Gulgeze HB, Zhang Y, Kadow KF, Cianci CW, Clarke J, Genovesi EV, Medina I, Lamb L, Wyde PR, Krystal M, Meanwell NA. Yu KL, et al. Among authors: gulgeze hb. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1115-22. doi: 10.1016/j.bmcl.2005.11.109. Epub 2005 Dec 20. Bioorg Med Chem Lett. 2006. PMID: 16368233
Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.
Yu KL, Sin N, Civiello RL, Wang XA, Combrink KD, Gulgeze HB, Venables BL, Wright JJ, Dalterio RA, Zadjura L, Marino A, Dando S, D'Arienzo C, Kadow KF, Cianci CW, Li Z, Clarke J, Genovesi EV, Medina I, Lamb L, Colonno RJ, Yang Z, Krystal M, Meanwell NA. Yu KL, et al. Among authors: gulgeze hb. Bioorg Med Chem Lett. 2007 Feb 15;17(4):895-901. doi: 10.1016/j.bmcl.2006.11.063. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17169560
Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Sin N, Venables BL, Combrink KD, Gulgeze HB, Yu KL, Civiello RL, Thuring J, Wang XA, Yang Z, Zadjura L, Marino A, Kadow KF, Cianci CW, Clarke J, Genovesi EV, Medina I, Lamb L, Krystal M, Meanwell NA. Sin N, et al. Among authors: gulgeze hb. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4857-62. doi: 10.1016/j.bmcl.2009.06.030. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19596574
Orally active fusion inhibitor of respiratory syncytial virus.
Cianci C, Yu KL, Combrink K, Sin N, Pearce B, Wang A, Civiello R, Voss S, Luo G, Kadow K, Genovesi EV, Venables B, Gulgeze H, Trehan A, James J, Lamb L, Medina I, Roach J, Yang Z, Zadjura L, Colonno R, Clark J, Meanwell N, Krystal M. Cianci C, et al. Antimicrob Agents Chemother. 2004 Feb;48(2):413-22. doi: 10.1128/AAC.48.2.413-422.2004. Antimicrob Agents Chemother. 2004. PMID: 14742189 Free PMC article.
Salicylamide inhibitors of influenza virus fusion.
Combrink KD, Gulgeze HB, Yu KL, Pearce BC, Trehan AK, Wei J, Deshpande M, Krystal M, Torri A, Luo G, Cianci C, Danetz S, Tiley L, Meanwell NA. Combrink KD, et al. Among authors: gulgeze hb. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1649-52. doi: 10.1016/s0960-894x(00)00335-8. Bioorg Med Chem Lett. 2000. PMID: 10937716