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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, Cox AD, Philips MR. Bivona TG, et al. Among authors: mor a. Mol Cell. 2006 Feb 17;21(4):481-93. doi: 10.1016/j.molcel.2006.01.012. Mol Cell. 2006. PMID: 16483930 Free article.
Compartmentalized Ras/MAPK signaling.
Mor A, Philips MR. Mor A, et al. Annu Rev Immunol. 2006;24:771-800. doi: 10.1146/annurev.immunol.24.021605.090723. Annu Rev Immunol. 2006. PMID: 16551266 Review.
396 results