Kuchel PW - Search Results

1

The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErg1.

Hill AP, Campbell TJ, Bansal PS, Kuchel PW, Vandenberg JI. Hill AP, et al. Among authors: kuchel pw. Biophys J. 2007 Sep 15;93(6):L32-4. doi: 10.1529/biophysj.107.114561. Epub 2007 Jul 13. Biophys J. 2007. PMID: 17631536 Free PMC article.

2

Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels.

Perrin MJ, Kuchel PW, Campbell TJ, Vandenberg JI. Perrin MJ, et al. Among authors: kuchel pw. Mol Pharmacol. 2008 Nov;74(5):1443-52. doi: 10.1124/mol.108.049056. Epub 2008 Aug 13. Mol Pharmacol. 2008. PMID: 18701618

3

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.

Ju P, Pages G, Riek RP, Chen PC, Torres AM, Bansal PS, Kuyucak S, Kuchel PW, Vandenberg JI. Ju P, et al. Among authors: kuchel pw. J Biol Chem. 2009 Jan 9;284(2):1000-8. doi: 10.1074/jbc.M806400200. Epub 2008 Nov 7. J Biol Chem. 2009. PMID: 18996846 Free article.

4

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

Ng CA, Perry MD, Tan PS, Hill AP, Kuchel PW, Vandenberg JI. Ng CA, et al. Among authors: kuchel pw. PLoS One. 2012;7(2):e31640. doi: 10.1371/journal.pone.0031640. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359612 Free PMC article.

5

The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics.

Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW. Vandenberg JI, et al. Among authors: kuchel pw. Eur Biophys J. 2004 Apr;33(2):89-97. doi: 10.1007/s00249-003-0338-3. Epub 2003 Sep 10. Eur Biophys J. 2004. PMID: 13680209 Review.

6

Structure of the pore-helix of the hERG K(+) channel.

Pages G, Torres AM, Ju P, Bansal PS, Alewood PF, Kuchel PW, Vandenberg JI. Pages G, et al. Among authors: kuchel pw. Eur Biophys J. 2009 Dec;39(1):111-20. doi: 10.1007/s00249-009-0433-1. Epub 2009 Mar 21. Eur Biophys J. 2009. PMID: 19305991

7

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

Ng CA, Hunter MJ, Perry MD, Mobli M, Ke Y, Kuchel PW, King GF, Stock D, Vandenberg JI. Ng CA, et al. Among authors: kuchel pw. PLoS One. 2011 Jan 13;6(1):e16191. doi: 10.1371/journal.pone.0016191. PLoS One. 2011. PMID: 21249148 Free PMC article.

8

Insights into hERG K+ channel structure and function from NMR studies.

Ng CA, Torres AM, Pagès G, Kuchel PW, Vandenberg JI. Ng CA, et al. Among authors: kuchel pw. Eur Biophys J. 2013 Jan;42(1):71-9. doi: 10.1007/s00249-012-0808-6. Epub 2012 May 3. Eur Biophys J. 2013. PMID: 22552870 Review.

9

The S1 helix critically regulates the finely tuned gating of Kv11.1 channels.

Phan K, Ng CA, David E, Shishmarev D, Kuchel PW, Vandenberg JI, Perry MD. Phan K, et al. Among authors: kuchel pw. J Biol Chem. 2017 May 5;292(18):7688-7705. doi: 10.1074/jbc.M117.779298. Epub 2017 Mar 9. J Biol Chem. 2017. PMID: 28280240 Free PMC article.

10

Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin.

Torres AM, Bansal P, Alewood PF, Bursill JA, Kuchel PW, Vandenberg JI. Torres AM, et al. Among authors: kuchel pw. FEBS Lett. 2003 Mar 27;539(1-3):138-42. doi: 10.1016/s0014-5793(03)00216-3. FEBS Lett. 2003. PMID: 12650941 Free article.

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