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Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM. Inai T, et al. Among authors: yancopoulos gd. Am J Pathol. 2004 Jul;165(1):35-52. doi: 10.1016/S0002-9440(10)63273-7. Am J Pathol. 2004. PMID: 15215160 Free PMC article.
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O'Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Huang J, et al. Among authors: yancopoulos gd. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7785-90. doi: 10.1073/pnas.1432908100. Epub 2003 Jun 12. Proc Natl Acad Sci U S A. 2003. PMID: 12805568 Free PMC article.
Impact of vessel maturation on antiangiogenic therapy in ovarian cancer.
Lu C, Thaker PH, Lin YG, Spannuth W, Landen CN, Merritt WM, Jennings NB, Langley RR, Gershenson DM, Yancopoulos GD, Ellis LM, Jaffe RB, Coleman RL, Sood AK. Lu C, et al. Among authors: yancopoulos gd. Am J Obstet Gynecol. 2008 Apr;198(4):477.e1-9; discussion 477.e9-10. doi: 10.1016/j.ajog.2007.12.028. Am J Obstet Gynecol. 2008. PMID: 18395047 Free PMC article.
494 results