Plate R - Search Results

1

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics.

Roumen L, Sanders MP, Pieterse K, Hilbers PA, Plate R, Custers E, de Gooyer M, Smits JF, Beugels I, Emmen J, Ottenheijm HC, Leysen D, Hermans JJ. Roumen L, et al. Among authors: plate r. J Comput Aided Mol Des. 2007 Aug;21(8):455-71. doi: 10.1007/s10822-007-9128-9. Epub 2007 Jul 24. J Comput Aided Mol Des. 2007. PMID: 17646925 Free PMC article.

2

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ. Roumen L, et al. Among authors: plate r. J Med Chem. 2010 Feb 25;53(4):1712-25. doi: 10.1021/jm901356d. J Med Chem. 2010. PMID: 20121113

3

Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.

Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ. Roumen L, et al. Among authors: plate r. J Comput Chem. 2011 Aug;32(11):2441-8. doi: 10.1002/jcc.21827. Epub 2011 May 19. J Comput Chem. 2011. PMID: 21598279

4

Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.

Minnaard-Huiban M, Emmen JM, Roumen L, Beugels IP, Cohuet GM, van Essen H, Ruijters E, Pieterse K, Hilbers PA, Ottenheijm HC, Plate R, de Gooyer ME, Smits JF, Hermans JJ. Minnaard-Huiban M, et al. Among authors: plate r. Endocrinology. 2008 Jan;149(1):28-31. doi: 10.1210/en.2007-0584. Epub 2007 Sep 20. Endocrinology. 2008. PMID: 17884944

5

Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor.

van Koppen CJ, de Gooyer ME, Karstens WJ, Plate R, Conti PG, van Achterberg TA, van Amstel MG, Brands JH, Wat J, Berg RJ, Lane JR, Miltenburg AM, Timmers CM. van Koppen CJ, et al. Among authors: plate r. Br J Pharmacol. 2012 Apr;165(7):2314-24. doi: 10.1111/j.1476-5381.2011.01709.x. Br J Pharmacol. 2012. PMID: 22014107 Free PMC article.

6

Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonist.

van Zeijl CJ, van Koppen CJ, Surovtseva OV, de Gooyer ME, Plate R, Conti P, Karstens WJ, Timmers M, Saeed P, Wiersinga WM, Miltenburg AM, Fliers E, Boelen A. van Zeijl CJ, et al. Among authors: plate r. J Clin Endocrinol Metab. 2012 May;97(5):E781-5. doi: 10.1210/jc.2011-2931. Epub 2012 Mar 14. J Clin Endocrinol Metab. 2012. PMID: 22419705

7

Synthesis and in vitro muscarinic activities of a series of 1,3-diazacycloalkyl carboxaldehyde oxime derivatives.

Plate R, Jans CG, Plaum MJ, de Boer T. Plate R, et al. Bioorg Med Chem. 2002 Apr;10(4):1143-52. doi: 10.1016/s0968-0896(01)00379-0. Bioorg Med Chem. 2002. PMID: 11836126

8

Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.

van Lierop MJ, Alkema W, Laskewitz AJ, Dijkema R, van der Maaden HM, Smit MJ, Plate R, Conti PG, Jans CG, Timmers CM, van Boeckel CA, Lusher SJ, McGuire R, van Schaik RC, de Vlieg J, Smeets RL, Hofstra CL, Boots AM, van Duin M, Ingelse BA, Schoonen WG, Grefhorst A, van Dijk TH, Kuipers F, Dokter WH. van Lierop MJ, et al. Among authors: plate r. PLoS One. 2012;7(11):e48385. doi: 10.1371/journal.pone.0048385. Epub 2012 Nov 12. PLoS One. 2012. PMID: 23152771 Free PMC article.

9

Synthesis and in vitro muscarinic activities of a series of 3-(pyrazol-3-yl)-1-azabicyclo[2.2.2]octanes.

Plate R, Plaum MJ, van der Hulst RG, de Boer T. Plate R, et al. Bioorg Med Chem. 2000 Feb;8(2):449-54. doi: 10.1016/s0968-0896(99)00299-0. Bioorg Med Chem. 2000. PMID: 10722168

10

Synthesis, and in vitro and in vivo muscarinic pharmacological properties of a series of 1,6-dihydro-5-(4H)-pyrimidinone oximes.

Plate R, Plaum MJ, Pintar P, Jans CG, de Boer T, Dijcks FA, Ruigt G, Andrews JS. Plate R, et al. Bioorg Med Chem. 1998 Sep;6(9):1404-20. doi: 10.1016/s0968-0896(98)00074-1. Bioorg Med Chem. 1998. PMID: 9801812

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