Beavers MP - Search Results

1

Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.

Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB 3rd. Myers MC, et al. Among authors: beavers mp. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4761-6. doi: 10.1016/j.bmcl.2007.06.091. Epub 2007 Jul 5. Bioorg Med Chem Lett. 2007. PMID: 17656088 Free PMC article.

2

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.

Myers MC, Shah PP, Beavers MP, Napper AD, Diamond SL, Smith AB 3rd, Huryn DM. Myers MC, et al. Among authors: beavers mp. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3646-51. doi: 10.1016/j.bmcl.2008.04.065. Epub 2008 May 1. Bioorg Med Chem Lett. 2008. PMID: 18499453 Free PMC article.

3

Molecular docking of cathepsin L inhibitors in the binding site of papain.

Beavers MP, Myers MC, Shah PP, Purvis JE, Diamond SL, Cooperman BS, Huryn DM, Smith AB 3rd. Beavers MP, et al. J Chem Inf Model. 2008 Jul;48(7):1464-72. doi: 10.1021/ci800085c. Epub 2008 Jul 4. J Chem Inf Model. 2008. PMID: 18598021 Free PMC article.

4

Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors.

Liu Z, Myers MC, Shah PP, Beavers MP, Benedetti PA, Diamond SL, Smith AB 3rd, Huryn DM. Liu Z, et al. Among authors: beavers mp. Comb Chem High Throughput Screen. 2010 May;13(4):337-51. doi: 10.2174/138620710791054303. Comb Chem High Throughput Screen. 2010. PMID: 20438448 Free PMC article.

5

Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB 3rd, Diamond SL. Shah PP, et al. Among authors: beavers mp. Mol Pharmacol. 2008 Jul;74(1):34-41. doi: 10.1124/mol.108.046219. Epub 2008 Apr 10. Mol Pharmacol. 2008. PMID: 18403718 Free PMC article.

6

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

Thurmond RL, Beavers MP, Cai H, Meduna SP, Gustin DJ, Sun S, Almond HJ, Karlsson L, Edwards JP. Thurmond RL, et al. Among authors: beavers mp. J Med Chem. 2004 Sep 23;47(20):4799-801. doi: 10.1021/jm0496133. J Med Chem. 2004. PMID: 15369380

7

Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors.

Shen L, Prouty C, Conway BR, Westover L, Xu JZ, Look RA, Chen X, Beavers MP, Roberts J, Murray WV, Demarest KT, Kuo GH. Shen L, et al. Among authors: beavers mp. Bioorg Med Chem. 2004 Mar 1;12(5):1239-55. doi: 10.1016/j.bmc.2003.09.047. Bioorg Med Chem. 2004. PMID: 14980636

8

Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.

Orsini MJ, Klein MA, Beavers MP, Connolly PJ, Middleton SA, Mayo KH. Orsini MJ, et al. Among authors: beavers mp. J Med Chem. 2007 Feb 8;50(3):462-71. doi: 10.1021/jm0609824. J Med Chem. 2007. PMID: 17266198

9

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.

Kuo GH, Prouty C, DeAngelis A, Shen L, O'Neill DJ, Shah C, Connolly PJ, Murray WV, Conway BR, Cheung P, Westover L, Xu JZ, Look RA, Demarest KT, Emanuel S, Middleton SA, Jolliffe L, Beavers MP, Chen X. Kuo GH, et al. Among authors: beavers mp. J Med Chem. 2003 Sep 11;46(19):4021-31. doi: 10.1021/jm030115o. J Med Chem. 2003. PMID: 12954055

10

Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.

Dudash J Jr, Zhang Y, Moore JB, Look R, Liang Y, Beavers MP, Conway BR, Rybczynski PJ, Demarest KT. Dudash J Jr, et al. Among authors: beavers mp. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4790-3. doi: 10.1016/j.bmcl.2005.07.021. Bioorg Med Chem Lett. 2005. PMID: 16143521

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