Saavedra JE - Search Results

1

V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO.

Chakrapani H, Showalter BM, Kong L, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Org Lett. 2007 Aug 16;9(17):3409-12. doi: 10.1021/ol701419a. Epub 2007 Jul 20. Org Lett. 2007. PMID: 17658755

2

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice.

Liu J, Li C, Waalkes MP, Clark J, Myers P, Saavedra JE, Keefer LK. Liu J, et al. Among authors: saavedra je. Hepatology. 2003 Feb;37(2):324-33. doi: 10.1053/jhep.2003.50063. Hepatology. 2003. PMID: 12540782

3

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice.

Li C, Liu J, Saavedra JE, Keefer LK, Waalkes MP. Li C, et al. Among authors: saavedra je. Toxicology. 2003 Aug 1;189(3):173-80. doi: 10.1016/s0300-483x(03)00129-x. Toxicology. 2003. PMID: 12832150

4

Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation.

Liu J, Li C, Qu W, Leslie E, Bonifant CL, Buzard GS, Saavedra JE, Keefer LK, Waalkes MP. Liu J, et al. Among authors: saavedra je. Mol Cancer Ther. 2004 Jun;3(6):709-14. Mol Cancer Ther. 2004. PMID: 15210857

5

The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level.

Qu W, Liu J, Fuquay R, Shimoda R, Sakurai T, Saavedra JE, Keefer LK, Waalkes MP. Qu W, et al. Among authors: saavedra je. Nitric Oxide. 2005 Mar;12(2):114-20. doi: 10.1016/j.niox.2005.01.005. Nitric Oxide. 2005. PMID: 15740985

6

Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug.

Waterhouse DJ, Saavedra JE, Davies KM, Citro ML, Xu X, Powell DA, Grimes GJ, Potti GK, Keefer LK. Waterhouse DJ, et al. Among authors: saavedra je. J Pharm Sci. 2006 Jan;95(1):108-15. doi: 10.1002/jps.20486. J Pharm Sci. 2006. PMID: 16315224

7

Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450.

Inami K, Nims RW, Srinivasan A, Citro ML, Saavedra JE, Cederbaum AI, Keefer LK. Inami K, et al. Among authors: saavedra je. Nitric Oxide. 2006 Jun;14(4):309-15. doi: 10.1016/j.niox.2006.01.003. Epub 2006 Mar 20. Nitric Oxide. 2006. PMID: 16545970

8

The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis.

Qu W, Liu J, Fuquay R, Saavedra JE, Keefer LK, Waalkes MP. Qu W, et al. Among authors: saavedra je. Cancer Lett. 2007 Oct 28;256(2):238-45. doi: 10.1016/j.canlet.2007.06.009. Epub 2007 Jul 20. Cancer Lett. 2007. PMID: 17658681 Free PMC article.

9

Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.

Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Org Lett. 2007 Oct 25;9(22):4551-4. doi: 10.1021/ol7019636. Epub 2007 Oct 5. Org Lett. 2007. PMID: 17918856

10

Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.

Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Bioorg Med Chem. 2008 Mar 1;16(5):2657-64. doi: 10.1016/j.bmc.2007.11.035. Epub 2007 Nov 17. Bioorg Med Chem. 2008. PMID: 18060792 Free PMC article.

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