Sowin TJ - Search Results

1

Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.

Wang L, Sullivan GM, Hexamer LA, Hasvold LA, Thalji R, Przytulinska M, Tao ZF, Li G, Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Merta P, Kovar P, Bouska JJ, Zhang H, Park C, Stewart KD, Sham HL, Sowin TJ, Rosenberg SH, Lin NH. Wang L, et al. Among authors: sowin tj. J Med Chem. 2007 Aug 23;50(17):4162-76. doi: 10.1021/jm070105d. Epub 2007 Jul 21. J Med Chem. 2007. PMID: 17658776

2

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.

Wang GT, Wang X, Wang W, Hasvold LA, Sullivan G, Hutchins CW, O'Conner S, Gentiles R, Sowin T, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Wang GT, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. doi: 10.1016/j.bmcl.2004.10.014. Bioorg Med Chem Lett. 2005. PMID: 15582430

3

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Wang GT, Li G, Mantei RA, Chen Z, Kovar P, Gu W, Xiao Z, Zhang H, Sham HL, Sowin T, Rosenberg SH, Lin NH. Wang GT, et al. J Med Chem. 2005 May 5;48(9):3118-21. doi: 10.1021/jm048989d. J Med Chem. 2005. PMID: 15857116

4

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.

Li G, Hasvold LA, Tao ZF, Wang GT, Gwaltney SL 2nd, Patel J, Kovar P, Credo RB, Chen Z, Zhang H, Park C, Sham HL, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2293-8. doi: 10.1016/j.bmcl.2006.01.028. Epub 2006 Jan 30. Bioorg Med Chem Lett. 2006. PMID: 16446090

5

Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.

Tao ZF, Wang L, Stewart KD, Chen Z, Gu W, Bui MH, Merta P, Zhang H, Kovar P, Johnson E, Park C, Judge R, Rosenberg S, Sowin T, Lin NH. Tao ZF, et al. J Med Chem. 2007 Apr 5;50(7):1514-27. doi: 10.1021/jm061247v. Epub 2007 Mar 13. J Med Chem. 2007. PMID: 17352464

6

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors.

Li G, Tao ZF, Tong Y, Przytulinska MK, Kovar P, Merta P, Chen Z, Zhang H, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6499-504. doi: 10.1016/j.bmcl.2007.09.088. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17931867

7

Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.

Tao ZF, Chen Z, Bui MH, Kovar P, Johnson E, Bouska J, Zhang H, Rosenberg S, Sowin T, Lin NH. Tao ZF, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6593-601. doi: 10.1016/j.bmcl.2007.09.063. Epub 2007 Sep 22. Bioorg Med Chem Lett. 2007. PMID: 17935989

8

Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.

Tong Y, Claiborne A, Stewart KD, Park C, Kovar P, Chen Z, Credo RB, Gu WZ, Gwaltney SL 2nd, Judge RA, Zhang H, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tong Y, et al. Among authors: sowin tj. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. doi: 10.1016/j.bmc.2007.01.012. Epub 2007 Jan 17. Bioorg Med Chem. 2007. PMID: 17287122

9

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.

Akritopoulou-Zanze I, Albert DH, Bousquet PF, Cunha GA, Harris CM, Moskey M, Dinges J, Stewart KD, Sowin TJ. Akritopoulou-Zanze I, et al. Among authors: sowin tj. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3136-40. doi: 10.1016/j.bmcl.2007.03.031. Epub 2007 Mar 15. Bioorg Med Chem Lett. 2007. PMID: 17391959

10

1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: extended exploration on phenyl ring substitutions and preliminary ADME/PK studies.

Tong Y, Claiborne A, Pyzytulinska M, Tao ZF, Stewart KD, Kovar P, Chen Z, Credo RB, Guan R, Merta PJ, Zhang H, Bouska J, Everitt EA, Murry BP, Hickman D, Stratton TJ, Wu J, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tong Y, et al. Among authors: sowin tj. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3618-23. doi: 10.1016/j.bmcl.2007.04.055. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17490879

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