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The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice.
Maki S, Miyauchi T, Kakinuma Y, Sakai S, Kobayashi T, Sugiyama F, Fukamizu A, Goto K, Yamaguchi I. Maki S, et al. Among authors: sakai s. Life Sci. 2004 Jan 16;74(9):1105-18. doi: 10.1016/j.lfs.2003.07.034. Life Sci. 2004. PMID: 14687651
Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathway.
Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I. Irukayama-Tomobe Y, et al. Among authors: sakai s. Circulation. 2004 Feb 24;109(7):904-10. doi: 10.1161/01.CIR.0000112596.06954.00. Epub 2004 Feb 16. Circulation. 2004. PMID: 14967736
Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway.
Ogata T, Miyauchi T, Sakai S, Takanashi M, Irukayama-Tomobe Y, Yamaguchi I. Ogata T, et al. Among authors: sakai s. J Am Coll Cardiol. 2004 Apr 21;43(8):1481-8. doi: 10.1016/j.jacc.2003.11.043. J Am Coll Cardiol. 2004. PMID: 15093887 Free article.
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