Percival MD - Search Results

1

Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.

Funicello M, Novelli M, Ragni M, Vottari T, Cocuzza C, Soriano-Lopez J, Chiellini C, Boschi F, Marzola P, Masiello P, Saftig P, Santini F, St-Jacques R, Desmarais S, Morin N, Mancini J, Percival MD, Pinchera A, Maffei M. Funicello M, et al. Among authors: percival md. PLoS One. 2007 Aug 1;2(8):e683. doi: 10.1371/journal.pone.0000683. PLoS One. 2007. PMID: 17668061 Free PMC article.

2

Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin.

Percival MD, Toulmond S, Coulombe N, Cromlish W, Desmarais S, Liu S, St-Jacques R, Gauthier JY, Fournier JF. Percival MD, et al. Biol Chem. 2010 Dec;391(12):1469-73. doi: 10.1515/BC.2010.140. Biol Chem. 2010. PMID: 20868234

3

Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools.

Desmarais S, Massé F, Percival MD. Desmarais S, et al. Among authors: percival md. Biol Chem. 2009 Sep;390(9):941-8. doi: 10.1515/BC.2009.092. Biol Chem. 2009. PMID: 19453281

4

Effect of cathepsin k inhibitor basicity on in vivo off-target activities.

Desmarais S, Black WC, Oballa R, Lamontagne S, Riendeau D, Tawa P, Duong LT, Pickarski M, Percival MD. Desmarais S, et al. Among authors: percival md. Mol Pharmacol. 2008 Jan;73(1):147-56. doi: 10.1124/mol.107.039511. Epub 2007 Oct 16. Mol Pharmacol. 2008. PMID: 17940194

5

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.

Falgueyret JP, Desmarais S, Oballa R, Black WC, Cromlish W, Khougaz K, Lamontagne S, Massé F, Riendeau D, Toulmond S, Percival MD. Falgueyret JP, et al. Among authors: percival md. J Med Chem. 2005 Dec 1;48(24):7535-43. doi: 10.1021/jm0504961. J Med Chem. 2005. PMID: 16302795

6

Primary amides as selective inhibitors of cathepsin K.

Léger S, Bayly CI, Black WC, Desmarais S, Falgueyret JP, Massé F, Percival MD, Truchon JF. Léger S, et al. Among authors: percival md. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4328-32. doi: 10.1016/j.bmcl.2007.05.024. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17544269

7

Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides.

Guay J, Falgueyret JP, Ducret A, Percival MD, Mancini JA. Guay J, et al. Among authors: percival md. Eur J Biochem. 2000 Oct;267(20):6311-8. doi: 10.1046/j.1432-1327.2000.01730.x. Eur J Biochem. 2000. PMID: 11012686 Free article.

8

An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.

Falgueyret JP, Black WC, Cromlish W, Desmarais S, Lamontagne S, Mellon C, Riendeau D, Rodan S, Tawa P, Wesolowski G, Bass KE, Venkatraman S, Percival MD. Falgueyret JP, et al. Among authors: percival md. Anal Biochem. 2004 Dec 15;335(2):218-27. doi: 10.1016/j.ab.2004.09.005. Anal Biochem. 2004. PMID: 15556560

9

Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.

Boulet L, Ouellet M, Bateman KP, Ethier D, Percival MD, Riendeau D, Mancini JA, Méthot N. Boulet L, et al. Among authors: percival md. J Biol Chem. 2004 May 28;279(22):23229-37. doi: 10.1074/jbc.M400443200. Epub 2004 Mar 11. J Biol Chem. 2004. PMID: 15016822 Free article.

10

Identification of a potent and selective non-basic cathepsin K inhibitor.

Li CS, Deschenes D, Desmarais S, Falgueyret JP, Gauthier JY, Kimmel DB, Léger S, Massé F, McGrath ME, McKay DJ, Percival MD, Riendeau D, Rodan SB, Thérien M, Truong VL, Wesolowski G, Zamboni R, Black WC. Li CS, et al. Among authors: percival md. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1985-9. doi: 10.1016/j.bmcl.2005.12.071. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413777

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