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Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 microl) blood samples.
Boghaert ER, Khandke KM, Sridharan L, Dougher M, DiJoseph JF, Kunz A, Hamann PR, Moran J, Chaudhary I, Damle NK. Boghaert ER, et al. Among authors: chaudhary i. Cancer Chemother Pharmacol. 2008 May;61(6):1027-35. doi: 10.1007/s00280-007-0560-2. Epub 2007 Aug 1. Cancer Chemother Pharmacol. 2008. PMID: 17668210
SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.
Golas JM, Lucas J, Etienne C, Golas J, Discafani C, Sridharan L, Boghaert E, Arndt K, Ye F, Boschelli DH, Li F, Titsch C, Huselton C, Chaudhary I, Boschelli F. Golas JM, et al. Among authors: chaudhary i. Cancer Res. 2005 Jun 15;65(12):5358-64. doi: 10.1158/0008-5472.CAN-04-2484. Cancer Res. 2005. PMID: 15958584
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Yu K, Lucas J, Zhu T, Zask A, Gaydos C, Toral-Barza L, Gu J, Li F, Chaudhary I, Cai P, Lotvin J, Petersen R, Ruppen M, Fawzi M, Ayral-Kaloustian S, Skotnicki J, Mansour T, Frost P, Gibbons J. Yu K, et al. Among authors: chaudhary i. Cancer Biol Ther. 2005 May;4(5):538-45. doi: 10.4161/cbt.4.5.1660. Epub 2005 May 28. Cancer Biol Ther. 2005. PMID: 15846106 Free article.
Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.
Venkatesan AM, Dehnhardt CM, Delos Santos E, Chen Z, Dos Santos O, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Gibbons J, Abraham RT, Chaudhary I, Mansour TS. Venkatesan AM, et al. Among authors: chaudhary i. J Med Chem. 2010 Mar 25;53(6):2636-45. doi: 10.1021/jm901830p. J Med Chem. 2010. PMID: 20166697
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.
Ayral-Kaloustian S, Gu J, Lucas J, Cinque M, Gaydos C, Zask A, Chaudhary I, Wang J, Di L, Young M, Ruppen M, Mansour TS, Gibbons JJ, Yu K. Ayral-Kaloustian S, et al. Among authors: chaudhary i. J Med Chem. 2010 Jan 14;53(1):452-9. doi: 10.1021/jm901427g. J Med Chem. 2010. PMID: 19928864
PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.
Venkatesan AM, Chen Z, dos Santos O, Dehnhardt C, Santos ED, Ayral-Kaloustian S, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Chaudhary I, Mansour TS. Venkatesan AM, et al. Among authors: chaudhary i. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5869-73. doi: 10.1016/j.bmcl.2010.07.104. Epub 2010 Jul 30. Bioorg Med Chem Lett. 2010. PMID: 20797855
Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor.
Mallon R, Feldberg LR, Lucas J, Chaudhary I, Dehnhardt C, Santos ED, Chen Z, dos Santos O, Ayral-Kaloustian S, Venkatesan A, Hollander I. Mallon R, et al. Among authors: chaudhary i. Clin Cancer Res. 2011 May 15;17(10):3193-203. doi: 10.1158/1078-0432.CCR-10-1694. Epub 2011 Feb 15. Clin Cancer Res. 2011. PMID: 21325073
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.
Berger DM, Dutia M, Powell D, Floyd MB, Torres N, Mallon R, Wojciechowicz D, Kim S, Feldberg L, Collins K, Chaudhary I. Berger DM, et al. Among authors: chaudhary i. Bioorg Med Chem. 2008 Oct 15;16(20):9202-11. doi: 10.1016/j.bmc.2008.09.009. Epub 2008 Sep 9. Bioorg Med Chem. 2008. PMID: 18815050
89 results