Antony S - Search Results

1

Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors.

Morrell A, Placzek M, Parmley S, Grella B, Antony S, Pommier Y, Cushman M. Morrell A, et al. Among authors: antony s. J Med Chem. 2007 Sep 6;50(18):4388-404. doi: 10.1021/jm070307+. Epub 2007 Aug 4. J Med Chem. 2007. PMID: 17676830

2

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.

Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L, Cushman M. Fox BM, et al. Among authors: antony s. J Med Chem. 2003 Jul 17;46(15):3275-82. doi: 10.1021/jm0300476. J Med Chem. 2003. PMID: 12852757

3

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.

Nagarajan M, Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Nagarajan M, et al. Among authors: antony s. J Med Chem. 2003 Dec 18;46(26):5712-24. doi: 10.1021/jm030313f. J Med Chem. 2003. PMID: 14667224

4

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.

Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Morrell A, et al. Among authors: antony s. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3659-63. doi: 10.1016/j.bmcl.2004.05.022. Bioorg Med Chem Lett. 2004. PMID: 15203138

5

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.

Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Xiao X, et al. Among authors: antony s. Bioorg Med Chem. 2004 Oct 1;12(19):5147-60. doi: 10.1016/j.bmc.2004.07.027. Bioorg Med Chem. 2004. PMID: 15351398

6

Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.

Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Xiao X, et al. Among authors: antony s. J Org Chem. 2004 Oct 29;69(22):7495-501. doi: 10.1021/jo048808f. J Org Chem. 2004. PMID: 15497974

7

Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.

Nagarajan M, Morrell A, Fort BC, Meckley MR, Antony S, Kohlhagen G, Pommier Y, Cushman M. Nagarajan M, et al. Among authors: antony s. J Med Chem. 2004 Nov 4;47(23):5651-61. doi: 10.1021/jm040025z. J Med Chem. 2004. PMID: 15509164

8

Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.

Antony S, Kohlhagen G, Agama K, Jayaraman M, Cao S, Durrani FA, Rustum YM, Cushman M, Pommier Y. Antony S, et al. Mol Pharmacol. 2005 Feb;67(2):523-30. doi: 10.1124/mol.104.003889. Epub 2004 Nov 5. Mol Pharmacol. 2005. PMID: 15531731

9

On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.

Xiao X, Antony S, Pommier Y, Cushman M. Xiao X, et al. Among authors: antony s. J Med Chem. 2005 May 5;48(9):3231-8. doi: 10.1021/jm050017y. J Med Chem. 2005. PMID: 15857129

10

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.

Xiao X, Miao ZH, Antony S, Pommier Y, Cushman M. Xiao X, et al. Among authors: antony s. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2795-8. doi: 10.1016/j.bmcl.2005.03.101. Bioorg Med Chem Lett. 2005. PMID: 15911256

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