DeBose-Boyd RA - Search Results

1

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.

Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, Song BL. Cao J, et al. Cell Metab. 2007 Aug;6(2):115-28. doi: 10.1016/j.cmet.2007.07.002. Cell Metab. 2007. PMID: 17681147 Free article.

2

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA. Sever N, et al. Mol Cell. 2003 Jan;11(1):25-33. doi: 10.1016/s1097-2765(02)00822-5. Mol Cell. 2003. PMID: 12535518 Free article.

3

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.

Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA. Sever N, et al. J Biol Chem. 2003 Dec 26;278(52):52479-90. doi: 10.1074/jbc.M310053200. Epub 2003 Oct 16. J Biol Chem. 2003. PMID: 14563840 Free article.

4

Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.

Song BL, DeBose-Boyd RA. Song BL, et al. J Biol Chem. 2004 Jul 2;279(27):28798-806. doi: 10.1074/jbc.M402442200. Epub 2004 Apr 16. J Biol Chem. 2004. PMID: 15090540 Free article.

5

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Sever N, Lee PC, Song BL, Rawson RB, Debose-Boyd RA. Sever N, et al. J Biol Chem. 2004 Oct 8;279(41):43136-47. doi: 10.1074/jbc.M406406200. Epub 2004 Jul 7. J Biol Chem. 2004. PMID: 15247248 Free article.

6

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.

Song BL, Javitt NB, DeBose-Boyd RA. Song BL, et al. Cell Metab. 2005 Mar;1(3):179-89. doi: 10.1016/j.cmet.2005.01.001. Cell Metab. 2005. PMID: 16054061 Free article.

7

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.

Song BL, Sever N, DeBose-Boyd RA. Song BL, et al. Mol Cell. 2005 Sep 16;19(6):829-40. doi: 10.1016/j.molcel.2005.08.009. Mol Cell. 2005. PMID: 16168377 Free article.

8

Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols.

Song BL, DeBose-Boyd RA. Song BL, et al. J Biol Chem. 2006 Sep 1;281(35):25054-61. doi: 10.1074/jbc.M605575200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831864 Free article.

9

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.

Lee JN, Song B, DeBose-Boyd RA, Ye J. Lee JN, et al. J Biol Chem. 2006 Dec 22;281(51):39308-15. doi: 10.1074/jbc.M608999200. Epub 2006 Oct 16. J Biol Chem. 2006. PMID: 17043353 Free article.

10

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation.

Lee PC, Nguyen AD, Debose-Boyd RA. Lee PC, et al. J Lipid Res. 2007 Feb;48(2):318-27. doi: 10.1194/jlr.M600476-JLR200. Epub 2006 Nov 7. J Lipid Res. 2007. PMID: 17090658 Free article.

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