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Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists.
Takahashi H, Bekkali Y, Capolino AJ, Gilmore T, Goldrick SE, Kaplita PV, Liu L, Nelson RM, Terenzio D, Wang J, Zuvela-Jelaska L, Proudfoot J, Nabozny G, Thomson D. Takahashi H, et al. Among authors: liu l. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5091-5. doi: 10.1016/j.bmcl.2007.07.021. Epub 2007 Jul 13. Bioorg Med Chem Lett. 2007. PMID: 17681466
Discovery of potent and selective PKC-theta inhibitors.
Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML. Cywin CL, et al. Among authors: liu lh. Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30. doi: 10.1016/j.bmcl.2006.09.056. Epub 2006 Oct 19. Bioorg Med Chem Lett. 2007. PMID: 17055721
Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.
Moriarty KJ, Winters M, Qiao L, Ryan D, DesJarlis R, Robinson D, Cook BN, Kashem MA, Kaplita PV, Liu LH, Farrell TM, Khine HH, King J, Pullen SS, Roth GP, Magolda R, Takahashi H. Moriarty KJ, et al. Among authors: liu lh. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5537-40. doi: 10.1016/j.bmcl.2008.09.017. Epub 2008 Sep 7. Bioorg Med Chem Lett. 2008. PMID: 18819794
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).
Winters MP, Robinson DJ, Khine HH, Pullen SS, Woska JR Jr, Raymond EL, Sellati R, Cywin CL, Snow RJ, Kashem MA, Wolak JP, King J, Kaplita PV, Liu LH, Farrell TM, DesJarlais R, Roth GP, Takahashi H, Moriarty KJ. Winters MP, et al. Among authors: liu lh. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5541-4. doi: 10.1016/j.bmcl.2008.09.016. Epub 2008 Sep 7. Bioorg Med Chem Lett. 2008. PMID: 18823779
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